1. Self-assembled emulsion gel based on modified chitosan and gelatin: Anti-inflammatory and improving cellular uptake of lipid-soluble actives.
- Author
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Li, Lihua, Zhao, Zhanli, Wang, Xin, Xu, Ke, Sun, Xinyu, Zhang, Hui, Dong, Mengna, Wang, Jiao, Li, Ruixia, Wei, Shuying, and Wang, Li
- Subjects
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EMULSIONS , *CHITOSAN , *GELATIN , *GALLIC acid , *SODIUM alginate , *ESSENTIAL oils , *ALGINATES - Abstract
To obtain a green carrier for intestinal targeted delivery, an emulsion gel was designed by the self-assembly between gelatin and Pickering emulsion based on gallic acid modified-chitosan nanoparticles (GCS NPs). The emulsion gels loaded with garlic essential oil (Geo) and curcumin (Cur) were abbreviated as GOEG and GCEG, respectively. Meanwhile, the sodium alginate bead loaded with Geo (GOEGS 3) and the bead loaded with Cur (GCEGS) were prepared as controls. Results demonstrated that the emulsion gels significantly improved the bioaccessibility of Geo and Cur, showing great intestinal targeting delivery properties comparable to that of sodium alginate beads. Moreover, Caco-2 cell experiments indicated that GOEG and GCEG displayed good biocompatibility and enhanced cellular uptake of Geo and Cur. The emulsion gels also exhibited excellent anti-inflammatory properties in the lipopolysaccharide-induced cell model, exhibiting great potential for clinical application. This work provides some references for the preparation of multifunctional emulsion gels with excellent delivery performance by a green method. [Display omitted] • The modified chitosan nanoparticles with good emulsification and biocompatibility. • Emulsion gel is formed by self-assembly of modified chitosan and gelatin. • Emulsion gel combines delivery and anti-inflammatory properties. • Emulsion gel can improve the cellular uptake of lipid-soluble actives. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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