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In the recent years, bio-functionalized noble metal doped advanced magnetics nanocomposite materials has been materialized as potential featured catalysts in diverse applications. In this connection, we report herein a novel biogenic lignin driven Au nanoparticle supported Fe 3 O 4 composite material. The procedure is free from any harsh reducing or stabilizing agent. Morphology and structural features were assessed following different physicochemical methodologies like FT-IR, FE-SEM, TEM, EDS, XRD, VSM and ICP-OES techniques. Thereafter, the [Fe 3 O 4 /Lignin/Au] material was successfully employed in the efficient reduction of different nitroarenes in aqueous medium. The process was monitored over UV–Vis spectroscopic study. Excellent yields were achieved with a range of diverse functionalized nitroarenes within 10–45 min of reaction. The nanocatalyst was recycled 10 times without any significant loss of catalytic activity. Distinctiveness of the material's activity was validated by comparing the results in the reduction of 4-nitrophenol. Furthermore, the prepared [Fe 3 O 4 /Lignin/Au] nanocomposite system exhibited outstanding antioxidant and anticancer effects against five lung cancer cell lines, such as, BICR 3, BICR 78, CALU 1, ChaGo-K-1, and A549. Cytotoxicity assay was determined in terms of % cell viability following MTT protocol. The corresponding IC 50 values were obtained as 47, 31, 19, 25, and 31 μg/mL respectively. [Display omitted] [ABSTRACT FROM AUTHOR]

In this article we report a novel Ag NPs fabricated chitosan-agarose composite functionalized core-shell type Fe 3 O 4 nanoparticle (Ag/CS-Agar@Fe 3 O 4). The biogenic material was analyzed over a number of physicochemical methods like, FT-IR, FE-SEM, TEM, EDX, XRD, VSM and ICP-OES. In catalytic exploration we aimed the synthesis of diverse 2 H -indazolo0- b ]phthalazine-trione derivatives via one-pot three component coupling of phathalalhydrazide, dimedone and different aldehydes. It afforded good to excellent yields under solvent-less conditions. Robustness of the catalyst was justified by catalyst recyclability for consecutive 10 times, hot filtration and leaching tests. Again, biological activity of the material was evaluated by studying the antioxidant and cytotoxicity properties over lung and liver cancer cell lines. Antioxidant potential of Ag/CS-Agar@Fe 3 O 4 was assessed by DPPH radical scavenging studies and the corresponding IC50 was found to be 96.57 μg/mL. Liver and lung cancer studies over Ag/CS-Agar@Fe 3 O 4 was carried out by MTT assay against HepG2 and A549 cell lines. The corresponding IC50 values were found as 192.35 and 365.28 μg/mL respectively. % Cell viability of the nanomaterial decreased dose dependently over both the cell lines without any cytotoxicity on normal cell line. The results demonstrates Ag/CS-Agar@Fe 3 O 4 nanocomposite to be an efficient chemotherapeutic drug against the lung and hepatocellular carcinoma cells. [Display omitted] [ABSTRACT FROM AUTHOR]