1. Synthesis and characterization of N-guanidinium chitosan/silica ionic hybrids as templates for calcium phosphate mineralization.
- Author
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Salama A and Hesemann P
- Subjects
- Calcium Phosphates chemistry, Carbon-13 Magnetic Resonance Spectroscopy, Guanidine chemistry, Ions, Silicon Dioxide chemistry, Spectrometry, X-Ray Emission, Spectroscopy, Fourier Transform Infrared, Thermogravimetry, X-Ray Diffraction, Calcium Phosphates chemical synthesis, Guanidine chemical synthesis, Minerals chemistry, Silicon Dioxide chemical synthesis
- Abstract
We report novel materials for calcium phosphate mineralization processes. These materials were synthesized via a three-step procedure starting from chitosan. In a first step, N-guanidinium-chitosan acetate was prepared via a direct guanylation reaction with cyanamide. This intermediate was then used as a cationic polymer substrate for attracting two functional anionic silica precursors, which subsequently allowed accessing new ionic hybrid materials via sol-gel chemistry. These N-guanidinium-chitosan acetate/silica hybrid materials, containing either sulfonate or carboxylate groups, were characterized using solid state
13 C NMR,29 Si NMR and FT-IR spectroscopy. Finally, these two ionic hybrids were used as templates for in-vitro biomimetic calcium phosphate mineralization using simulated body fluid solution. We could show that the two ionic hybrids act as versatile templates for biomineralization, inducing the formation of hydroxyapatite, as proved from XRD, SEM, EDX, TEM and TGA. The current results suggest that the new ionic hybrids may be promising candidates for bone tissue engineering applications., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interests., (Copyright © 2020 Elsevier B.V. All rights reserved.)- Published
- 2020
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