Search

Chronic cutaneous wounds present a significant challenge for healthcare providers globally, with the risk of bacterial infections emerging as a particularly concerning issue. There is an increasing need to employ a combination of diverse antibacterial strategies to address infections comprehensively in chronic wounds. This study introduces a highly efficient antibacterial platform that encapsulates the NO precursor (BNN6) into β-cyclodextrin-modified hemin-bearing polydopamine nanoparticles called NO/CHPDA. These nanoparticles are seamlessly integrated into a hydrogel composite comprised of L-arginine grafted chitosan (Arg-CS) and oxide dextrans (oDex). The amalgamation of photothermal therapy (PTT), chemodynamic therapy (CDT), and nitric oxide (NO) antibacterial strategies within the NO/CHPDA@Arg-CS/oDex nanocomposite hydrogel demonstrates a synergistic and highly effective capacity to eradicate bacteria and accelerate the wound healing process in vivo. Remarkably, this nanocomposite hydrogel maintains excellent biocompatibility and induces minimal side effects. The resulting nanocomposite hydrogel represents a promising therapeutic solution for treating bacterial infections in wound healing applications. [Display omitted] [ABSTRACT FROM AUTHOR]

The development of environmental-friendly antibacterial agents with high efficiency and low cost has become the focus of attention. In this work, the Ag nanoparticles doped into chitosan (Ag NPs-CS) were synthesized by a green and facile method, and the samples were characterized by UV–Vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The antibacterial tests implied that Ag NPs-CS obtained from glucose (G-Ag NPs-CS) exhibited the excellent antimicrobial activities against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) microbes. Besides, the utilization of antibacterial agents in polymeric materials plays an significant role in healthy living. The aim is to impart the antibacterial properties and maintain/improve the mechanical properties. Therefore, the G-Ag NPs-CS with 5 wt% Ag was chosen as the optimal additive to endow polypropylene with antimicrobial activity via a simple melt blending method. The results demonstrated that the suppression of bacteria proliferation was enhanced with increasing the amount of antibacterial agent, and the microorganisms were almost killed when the content reached to 8 wt%. Meanwhile, the considerable improvement in elastic modulus and impact strength along with a slight decrease of elongation at break provided the evidence that Ag NPs-CS/PP nanocomposites were the promising candidate for practical applications. Unlabelled Image [ABSTRACT FROM AUTHOR]