Search

Yam (Dioscorea spp.), known as an edible and medicinal tuber crop in China, has been used historically for the treatment of diabetes, diarrhea, asthma, and other ailments in traditional Chinese medicine. Moreover, it has been consumed as starchy food for thousands of years in China. Modern phytochemistry and pharmacological experiments have been proved that non-starch polysaccharide is one of the main bioactive substances of yam. Many studies have been focused on the isolation and identification of polysaccharides and their bioactivities of Chinese yam. However, due to the difference in the variety of raw materials and the method of polysaccharides extracting, the structure and biological activity of the obtained polysaccharides also differ. It has been demonstrated that Chinese yam polysaccharide has various important biological activities, such as hypoglycemia, immunomodulatory, antioxidant, and antitumor activities. This paper is aimed at summarizing previous and current references of the isolation processes, structural features and bioactivities of yam polysaccharides. The review will serve as a useful reference material for further investigation and application of yam polysaccharides in functional foods and medicine fields. [ABSTRACT FROM AUTHOR]

The discovery of active constituents from food plants is an important area of research in pharmaceutical sciences. Aralia echinocaulis is a medicinal food plant that is mainly used to prevent or treat rheumatoid arthritis in China. This paper reported the isolation, purification and bioactivity of a polysaccharide (HSM-1-1) from A. echinocaulis. Its structural features were analyzed according to the molecular weight distribution, monosaccharide composition, gas chromatography–mass spectrometry (GC–MS) and nuclear magnetic resonance spectra. The results indicated that HSM-1-1 was a new 4- O -methylglucuronoxylan mainly composed of xylan and 4- O -methyl glucuronic acid with the molecular weight of 1.6 × 104 Da. Furthermore, the antitumor and anti-inflammatory activities of HSM-1-1 in vitro were investigated, and the results showed that HSM-1-1 had potent proliferation inhibition activity on colon cancer cell SW480 with an inhibition rate of 17.57 ± 1.03 % at a concentration of 600 μg/mL, as measured via MTS methods. To our knowledge, this is the first report of a polysaccharide structure obtained from A. echinocaulis and its bioactivities, and its potential as an adjuvant natural product with antitumor effects is shown. [ABSTRACT FROM AUTHOR]

Periplaneta americana (P. americana), which is widely used for wound healing in China, produces a large amount of solid waste (P. americana remnant) after pharmaceutical production extraction. P. americana remnant chitosan (PAC) has a low molecular weight, low crystallinity, and easily modifiable structural properties. In this study, PAC and P. americana remnant polysaccharide (PAP) were used as raw materials to prepare a composite film (PAPCF). The good biocompatibility of the composite film was verified by cell proliferation assays and protein adsorption assays. The bioactivity of the composite film was assessed by antibacterial and in vivo/vitro antioxidant assays to evaluate its potential as a wound dressing. The wound healing experiment revealed that PAPCF improved wound closure and collagen deposition, decreased reactive oxygen species levels, and attenuated the inflammatory response, enabling rapid wound healing from the inflammatory phase to the proliferative phase in mice. Additionally, PAPCF was administered only once, reducing the chance of infection from multiple deliveries. In summary, this paper presents an easy-to-administer, cost-effective, and effective dressing candidate for wound treatment based on the environmental concept of resource reuse. [Display omitted] • Providing new ideas for the effective utilization of Periplaneta Americana remnants. • Polysaccharide/chitosan films (PAPCF) have a rough surface for rapid wound adhesion. • PAPCF could be administered in a single dose for its rapid biodegradation rate. • PAPCF showed remarkable antibacterial, antioxidant and anti-inflammatory effects that improved wound healing rates. [ABSTRACT FROM AUTHOR]