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Electrospinning is a technology for fabricating ultrafine fibers from natural or synthetic polymers that have novel or enhanced functional properties. These fibers have found applications in a diverse range of fields, including the food, medicine, cosmetics, agriculture, and chemical industries. However, the tendency for electrospun nanofibers to dissociate when exposed to certain environmental conditions limits many of their practical applications. The structural integrity and functional attributes of these nanofibers can be improved using physical and/or chemical crosslinking methods. This review article discusses the formation of polymeric nanofibers using electrospinning and then describes how different crosslinking methods can be used to enhance their mechanical, thermal, and biological attributes. Methods for optimizing the crosslinking reactions are discussed, including proper selection of crosslinker type and reaction conditions. Then, food, medical, and separation applications of crosslinked electrospun fibers are assessed, including in bone and skin tissue engineering, wound healing, drug delivery, air filtration, water filtration, oil removal, food packaging, food preservation, and bioactive delivery. Finally, areas where future research are needed are highlighted, as well as possible future applications of crosslinked nanofibers., Competing Interests: Declaration of competing interest The authors declare no competing interests., (Copyright © 2024 Elsevier B.V. All rights reserved.)