1. Enhancing the understanding of SARS-CoV-2 protein with structure and detection methods: An integrative review.
- Author
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Wang, Ruiqi, Lu, Song, Deng, Fanyu, Wu, Liqing, Yang, Guowu, Chong, Siying, and Liu, Yahui
- Subjects
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PROTEIN structure , *SARS-CoV-2 , *PANDEMIC preparedness , *VIRAL proteins , *COVID-19 , *POLYMERASE chain reaction - Abstract
As the rapid and accurate screening of infectious diseases can provide meaningful information for outbreak prevention and control, as well as owing to the existing limitations of the polymerase chain reaction (PCR), it is imperative to have new and validated detection techniques for SARS-CoV-2. Therefore, the rationale for outlining the techniques used to detect SARS-CoV-2 proteins and performing a comprehensive comparison to serve as a practical benchmark for future identification of similar viral proteins is clear. This review highlights the urgent need to strengthen pandemic preparedness by emphasizing the importance of integrated measures. These include improved tools for pathogen characterization, optimized societal precautions, the establishment of early warning systems, and the deployment of highly sensitive diagnostics for effective surveillance, triage, and resource management. Additionally, with an improved understanding of the virus' protein structure, considerable advances in targeted detection, treatment, and prevention strategies are expected to greatly improve our ability to respond to future outbreaks. [Display omitted] • This review features meaningful information for preventing and controlling outbreaks. • This is a clear summary of the structure and function of SARS-CoV-2 proteins. • A comprehensive comparison of relevant SARS-CoV-2 protein assays is revealed. • This review aims to provide a future reference for detecting similar viral proteins. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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