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In this paper, a new delayed fractional-order model including susceptible migratory birds, infected migratory birds and predators is proposed to discuss the spread of diseases among migratory birds. Fear of predators is considered in the model, as fear can reduce the reproduction rate and disease transmission rate among prey. First, some basic mathematical results of the proposed model are discussed. Then, time delay is regarded as a bifurcation parameter, and the delay-induced bifurcation conditions for such an uncontrolled system are established. A novel periodic pulse feedback controller is proposed to suppress the bifurcation phenomenon. It is found that the control scheme can successfully suppress the bifurcation behavior of the system, and the pulse width can be arbitrarily selected on the premise of ensuring the control effect. Compared with the traditional time-delay feedback controller, the control scheme proposed in this paper has more advantages in practical application, which not only embodies the advantages of low control cost and easy operation but also caters to the periodic changes of the environment. The proposed control scheme, in particular, remains effective even after the system has been disrupted by a constant. Numerical simulation verifies the correctness of the theoretical results. [ABSTRACT FROM AUTHOR]

This work investigates a prey–predator model featuring a Holling-type II functional response, in which the fear effect of predation on the prey species, as well as prey refuge, are considered. Specifically, the model assumes that the growth rate of the prey population decreases as a result of the fear of predators. Moreover, the detection of the predator by the prey species is subject to a delay known as the fear response delay, which is incorporated into the model. The paper establishes the preliminary conditions for the solution of the delayed model, including positivity, boundedness and permanence. The paper discusses the existence and stability of equilibrium points in the model. In particular, the paper considers the discrete delay as a bifurcation parameter, demonstrating that the system undergoes Hopf bifurcation at a critical value of the delay parameter. The direction and stability of periodic solutions are determined using central manifold and normal form theory. Additionally, the global stability of the model is established at axial and positive equilibrium points. An extensive numerical simulation is presented to validate the analytical findings, including the continuation of the equilibrium branch for positive equilibrium points. [ABSTRACT FROM AUTHOR]

In this paper, an SIRS epidemic model using Grunwald–Letnikov fractional-order derivative is formulated with the help of a nonlinear system of fractional differential equations to analyze the effects of fear in the population during the outbreak of deadly infectious diseases. The criteria for the spread or extinction of the disease are derived and discussed on the basis of the basic reproduction number. The condition for the existence of Hopf bifurcation is discussed considering fractional order as a bifurcation parameter. Additionally, using the Grunwald–Letnikov approximation, the simulation is carried out to confirm the validity of analytic results graphically. Using the real data of COVID-19 in India recorded during the second wave from 15 May 2021 to 15 December 2021, we estimate the model parameters and find that the fractional-order model gives the closer forecast of the disease than the classical one. Both the analytical results and numerical simulations presented in this study suggest different policies for controlling or eradicating many infectious diseases. [ABSTRACT FROM AUTHOR]

In this paper, a stage structure predator–prey model consisting of three nonlinear ordinary differential equations is proposed and analyzed. The prey populations are divided into two parts: juvenile prey and adult prey. From extensive experimental data, it has been found that prey fear of predators can alter the physiological behavior of individual prey, and the fear effect reduces their reproductive rate and increases their mortality. In addition, we also consider the presence of constant ratio refuge in adult prey populations. Moreover, we consider the existence of intraspecific competition between adult prey species and predator species separately in our model and also introduce the gestation delay of predators to obtain a more realistic and natural eco-dynamic behaviors. We study the positivity and boundedness of the solution of the non-delayed system and analyze the existence of various equilibria and the stability of the system at these equilibria. Next by choosing the intra-specific competition coefficient of adult prey as bifurcation parameter, we demonstrate that Hopf bifurcation may occur near the positive equilibrium point. Then by taking the gestation delay as bifurcation parameter, the sufficient conditions for the existence of Hopf bifurcation of the delayed system at the positive equilibrium point are given. And the direction of Hopf bifurcation and the stability of the periodic solution are analyzed by using the center manifold theorem and normal form theory. What's more, numerical experiments are performed to test the theoretical results obtained in this paper. [ABSTRACT FROM AUTHOR]

In this paper, a new generalized non-monotonic and saturated incidence rate was introduced into a susceptible-infected-susceptible (SIS) epidemic model to account for inhibitory effect and crowding effect. The dynamic properties of the model were studied by qualitative theory and bifurcation theory. It is shown that when the influence of psychological factors is large, the model has only disease-free equilibrium point, and this disease-free equilibrium point is globally asymptotically stable; when the influence of psychological factors is small, for some parameter conditions, the model has a unique endemic equilibrium point, which is a cusp point of co-dimension two, and for other parameter conditions the model has two endemic equilibrium points, one of which could be weak focus or center. In addition, the results of the model undergoing saddle-node bifurcation, Hopf bifurcation and Bogdanov–Takens bifurcation as the parameters vary were also proved. These results shed light on the impact of psychological behavior of susceptible people on the disease transmission. [ABSTRACT FROM AUTHOR]

Pine wilt disease is a destructive forest disease with strong infectivity, a wide spread range and high difficulty in prevention and control. Since controlling Monochamus alternatus, the vector of pine wood nematode (Bursaphelenchus xylophilus) can reduce the occurrence of pine wilt disease efficiently, the parasitic natural enemy of M. alternatus, Dastarcus helophoroides, is introduced in this paper. Considering the influence of parasitic time of D. helophoroides on the control effect, based on the mutualistic symbiosis and parasitic relationship among pine wood nematode, M. alternatus and D. heloporoides, this paper establishes a pine wood nematode prevention and control model with delay. Then, the stability of positive equilibrium and the existence of Hopf bifurcation are discussed. Besides, we obtain the normal form of Hopf bifurcation by applying the multiple time scales method. Finally, numerical simulations with two sets of meaningful parameters selected by means of statistical analysis are carried out to support the theoretical findings. Through the comparative analysis of numerical simulations, the factors affecting the control effect of pine wilt disease are obtained, and some suggestions are put forward for practical control in the forest. [ABSTRACT FROM AUTHOR]

The sterile insect technique (SIT) has been applied as an alternative method to reduce or eradicate mosquito-borne diseases. To explore the impact of the sterile mosquitoes on controlling the wild mosquito populations, in this paper, we further extend the work in [J. Li, New revised simple models for interactive wild and sterile mosquito populations and their dynamics, J. Biol. Dyn. 11(S2) (2017) 316–333] and formulate delayed models for interactive wild and sterile mosquitoes, which can depict wild mosquito population undergoing distinct stages of development during a lifetime. By performing mathematical analysis, the threshold dynamics of the proposed models are explored, respectively. In particular, Hopf bifurcation phenomena are observed as the delay τ is varying. Numerical examples illustrate our findings. [ABSTRACT FROM AUTHOR]

In this paper, we consider the long-term sustainability of the northeast Korean pine. We propose a class of natural Korean pine population system with time delay and diffusion term. First, by analyzing the roots distribution of the characteristic equation, we study the stability of the model system with diffusion terms and prove the occurrence of Hopf bifurcation. Second, we introduce lactation time delay into a population model with a diffusion term, based on stability theory of ordinary differential equation, norm form methods and center manifold theorem, the stability of bifurcating periodic solutions and the relevant formula for the direction of Hopf bifurcation are given. Finally, some numerical simulations are given. [ABSTRACT FROM AUTHOR]

The spread of infectious diseases often presents the emergent properties, which leads to more difficulties in prevention and treatment. In this paper, the SIR model with both delay and network is investigated to show the emergent properties of the infectious diseases' spread. The stability of the SIR model with a delay and two delay is analyzed to illustrate the effect of delay on the periodic outbreak of the epidemic. Then the stability conditions of Hopf bifurcation are derived by using central manifold to obtain the direction of bifurcation, which is vital for the generation of emergent behavior. Also, numerical simulation shows that the connection probability can affect the types of the spatio-temporal patterns, further induces the emergent properties. Finally, the emergent properties of COVID-19 are explained by the above results. [ABSTRACT FROM AUTHOR]

In this paper, we study a diffusive predator–prey model with hyperbolic mortality and prey-taxis under homogeneous Neumann boundary condition. We first analyze the influence of prey-taxis on the local stability of constant equilibria. It turns out that prey-taxis has influence on the stability of the unique positive constant equilibrium, but has no influence on the stability of the trivial equilibrium and the semi-trivial equilibrium. We then derive Hopf bifurcation and steady state bifurcation related to prey-taxis, which imply that the prey-taxis plays an important role in the dynamics. [ABSTRACT FROM AUTHOR]

This paper proposes a diffusive predator–prey model with Allee effect, time delay and anti-predator behavior. First, the existence and stability of all equilibria are analyzed and the conditions for the appearance of the Hopf bifurcation are studied. Using the normal form and center manifold theory, the formulas which can determine the direction, period and stability of Hopf bifurcation are obtained. Numerical simulations show that the Allee effect can determine the survival abundance of the prey and predator populations, and anti-predator behavior can greatly improve the stability of the coexisting equilibrium. [ABSTRACT FROM AUTHOR]

This paper presents a brucellosis disease model with reaction–diffusion and time delay. The model takes into account both the direct and indirect transmission of infected animals and pathogens in the environment. By analyzing the associated characteristic equation, the local stability of the unique positive equilibrium point is established. The existence of Hopf bifurcations at the positive equilibrium point is also examined by considering the discrete time delay as a bifurcation parameter. Additionally, an optimal control analysis is conducted to minimize disease outbreaks and control costs. This includes reducing the exposure of susceptible animals to infected animals, removing infected animals from herds, and reducing emissions of brucella into the environment. By constructing Hamiltonian function and applying Pontryagin’s maximum principle, the necessary conditions for the existence of optimal control are given. Finally, the existence of bifurcation periodic solutions and the effectiveness of control strategies are illustrated through numerical simulations. [ABSTRACT FROM AUTHOR]

In this paper, a delayed cytokine-enhanced viral infection model incorporating nonlinear incidence and immune response is proposed and studied. The global stabilities of the equilibria of the model are characterized by constructing suitable Lyapunov functionals. The existence and properties of local Hopf bifurcation are discussed by regarding the immunity delay as the bifurcation parameter. Moreover, the global existence of Hopf bifurcation has been proved by regarding the immune delay as the bifurcation parameter. Numerical simulations are carried out to validate the obtained results. The results show that ignoring the cytokine-enhanced effect makes the infection risk underevaluated. The simulations show that increasing the immune delay destabilizes the model and generates a Hopf bifurcation and stability switches occurs. Moreover, it shows that immune delay may dominate the intracellular delays in such a viral infection model which means that the immune system of the host itself is complicated during virus infection. [ABSTRACT FROM AUTHOR]

In this paper, we formulate and study a fractional-order network model with four neurons, bidirectional ring structure and self-delay feedback. For the scenario of non-identical neurons, we develop a new algebraic technique to deal with the characteristic equation with e − 4 s τ (τ is the self-feedback delay) term and thus establish the easy-to-check criteria to determine the Hopf bifurcation point of self-feedback delay by fixing communication delay in its stable interval. For the scenario of identical neurons, we apply the crossing curves method to the fractional functional equations and thus procure the Hopf bifurcation curve. The obtained results accommodate the fact that the model cannot preserve its stability behavior when the self-feedback delay crosses the Hopf bifurcation point in the positive direction. Finally, we deliberate on the correctness of our methodology through two demonstration examples. [ABSTRACT FROM AUTHOR]

Eco-epidemiological model plays a crucial role in maintaining ecological balance and biological invasions. In this paper, we propose a predator–prey model where the predator population is infected by the disease. The non-negativity and boundedness of the solution are addressed. The existence and stability of equilibrium are discussed by an invasive approach. Numerical simulations are used to demonstrate the competitive and exclusion, and oscillation behaviors of the model. Interestingly, the predation rate of the infected predator is shown to have far-reaching implications for the structure and stability of ecological communities. [ABSTRACT FROM AUTHOR]

In this paper, a new delayed within host model for dengue fever with immune response and Beddington–DeAngelis incidence is investigated. The basic reproduction number is computed. In addition, a detailed analysis on the local and global dynamics of the model is conducted. Finally, sensitivity analysis is carried out on basic reproduction number and numerical simulations are given to elucidate our theoretical results. [ABSTRACT FROM AUTHOR]

In this paper, we investigate the dynamics of a reaction-diffusion Nicholson's blowflies equation with advection. The stability of positive steady state and existence of Hopf bifurcation are obtained by analyzing the distribution of the eigenvalues. Moreover, by using the center manifold theory and normal form method, an explicit algorithm for determining the direction and stability of the Hopf bifurcation is derived. Meanwhile, we find out that the bifurcation value is increasing with respect to the advection rate. Finally, numerical results demonstrate that the advection term causes the population to move from upstream to downstream, which also indicates that advection term plays a key role in the description and interpretation of some common natural phenomena. [ABSTRACT FROM AUTHOR]

This paper expounds the bifurcations of two-delayed fractional-order neural networks (FONNs) with multiple neurons. Leakage delay or communication delay is viewed as a bifurcation parameter, stability zones and bifurcation conditions with respect to them are commendably established, respectively. It declares that both leakage delay and communication delay immensely influence the stability and bifurcation of the developed FONNs. The explored FONNs illustrate superior stability performance if selecting a lesser leakage delay or communication delay, and Hopf bifurcation generates once they overstep their critical values. The verification of the feasibility of the developed analytic results is implemented via numerical experiments. [ABSTRACT FROM AUTHOR]

In this paper, a delayed fractional-order epidemic model with general incidence rate and incubation period is proposed for the Corona Virus Disease 2019 (COVID-19) pandemic. The corresponding sufficient conditions are established to analyze the existence and stability of disease-free equilibrium and endemic equilibrium of the proposed model. The conditions for the existence of Hopf bifurcation are obtained by selecting the time delay as the bifurcation parameter. The control strategies for the COVID-19 pandemic are designed, and the corresponding delay fractional order optimal control problem (DFOCP) is analyzed based on the generalized Euler–Lagrange equation. The parameters of the model are identified based on the data of multiple types of the COVID-19 pandemic. Further, the effectiveness of the model in describing the trend of the COVID-19 pandemic is verified. Based on the results of parameter identification, the influence of incubation period on the COVID-19 pandemic is discussed. The forward–backward sweep method (FBSM) is adopted to numerically solve DFOCP, and the control effects under different control measures are analyzed. [ABSTRACT FROM AUTHOR]

The menstrual cycle of fertile female is regulated by multiple organs and hormones, controlling the reproductive health and fertility of females. This paper is dedicated to exploring how two negative feedback loops regulate and influence the dynamic behavior of the menstrual cycle. We simplified the regulation circuit of the menstrual cycle into a nonlinear differential equation with two time delays. This simplified mathematical model integrates the hypothalamus–pituitary–ovary primary negative feedback loop and the negative feedback auxiliary loop between the ovary and the pituitary. We investigated the delay-dependent conditions for the stability of the model’s equilibrium points and also demonstrated the presence of Hopf bifurcations. Theoretical analysis suggests that the primary feedback loop is the major factor driving oscillation in the system. Further numerical simulations indicate that the negative feedback auxiliary loop allows the system to adjust its amplitude while maintaining the robustness of the cycle length. Consequently, the results obtained from this model provide new insights into the regulation of oscillations in menstrual cycle irregularities. [ABSTRACT FROM AUTHOR]

Due to the random search of species and from the economic point of view, combined harvesting is more suitable than selective harvesting. Thus, we have developed and analyzed a prey–predator model with the combined effect of nonlinear harvesting in this research paper. Nonlinear harvesting possesses multiple predator-free and interior equilibrium points in the dynamical system. We have examined the local stability analysis of all the equilibrium points. Besides these various types, rich and complex dynamical behaviors such as backward, saddle-node, Hopf and Bogdanov–Takens (BT) bifurcations, homo-clinic loop and limit cycles appear in this model. Furthermore, interesting phenomena like bi-stability and tri-stability occur in our model between the different equilibrium points. Also, we have derived different threshold values of predator harvesting parameters and prey environmental carrying capacity from these bifurcations to obtain the different harvesting strategies for both species. We have observed that the extinction of predator species may not happen due to backward bifurcation, although a stable predator-free equilibrium (PFE) exists. Finally, numerical simulations are discussed using MATLAB to verify all the theoretical results. [ABSTRACT FROM AUTHOR]

In this paper, the dynamical behaviors of a new cytokine-enhanced HIV infection model with intracellular delay τ1, virus replication delay τ2 and immune response delay τ3 are investigated. The positivity and boundedness of all solutions for the model with non-negative initial values have been proved. Moreover, two important biological parameters, called the virus reproductive number R0 and the antibody immune reproductive number R1 are established. By constructing suitable Lyapunov functionals and using LaSalle’s invariance principle, the global dynamics of the equilibria is completely determined by R0 and R1. On the one hand, the results show that intracellular delay τ1, viral replication delay τ2 and immune response delay τ3 have no effect on the stability of E0, E1, and if τ1 ≥ 0, τ2 ≥ 0, τ3 = 0, the endemic equilibrium with the presence of antibody response E2 is globally asymptotically stable. On the other hand, when τ1 ≥ 0, τ2 ≥ 0, τ3 > 0, numerical analysis confirms the theorems and suggests that time delay play a positive role in virus infection, with the increase of τ3, the dynamic behavior of the equilibrium E2 will change as follows: locally asymptotically stable → unstable; Hopf bifurcation appears. [ABSTRACT FROM AUTHOR]

The dynamical behaviors for a delay-diffusion housefly equation with two kinds of Dirichlet boundary conditions are considered in this paper. The existence and uniqueness of the steady state solutions are investigated, and the stability of the constant steady state solutions is obtained by using qualitative theory. The existence of Hopf bifurcation near the positive constant steady state solution is discussed and the expressions which can identify the bifurcation properties, including the stability of the bifurcating periodic solution and the bifurcation direction, are presented. [ABSTRACT FROM AUTHOR]

In this paper, we investigate the mathematical analysis of a mathematical model describing the virotherapy treatment of a cancer with logistic growth and the effect of viral cycle presented by a time delay. The cancer population size is divided into uninfected and infected compartments. Depending on time delay, we prove the positivity and boundedness and the stability of equilibria. We give conditions on which the viral cycle leads to “Jeff’s phenomenon” observed in laboratory and causes oscillations in cancer size via Hopf bifurcation theory. We establish an algorithm that determines the bifurcation elements via center manifold and normal form theories. We give conditions which lead to a supercritical or subcritical bifurcation. We end with numerical simulations illustrating our theoretical results. [ABSTRACT FROM AUTHOR]

In this paper, we propose a cancer virotherapy model with virus lytic cycle and diffusion term. Spatiotemporal dynamic properties of the cancer virotherapy system are studied. First, by analyzing the roots distribution of the characteristic equation and transcendental equation, the conditions for the local stability of the constant equilibria of system are given. Second, we select delay as the bifurcation parameter, the existence conditions of Hopf bifurcation are given. By using the center manifold theory and normal form method of partial functional differential equation, the detailed formulae for determining the direction of Hopf bifurcation and the stability of bifurcating periodic solutions are given. Finally, some numerical simulations are given. [ABSTRACT FROM AUTHOR]

In this paper, a delayed differential model of citrus Huanglongbing infection is analyzed, in which the latencies of the citrus tree and Asian citrus psyllid are considered as two time delay factors. We compute the equilibrium points and the basic reproductive numbers with and without time delays, i.e. R 0 and R ̃ 0 , and then show that R ̃ 0 completely determines the local stability of the disease-free equilibrium. Moreover, the conditions for the existence of transcritical bifurcation are derived from Sotomayor's Theorem. The stability of the endemic equilibrium and the existence of Hopf bifurcation are investigated in four cases: (1) τ 1 = τ 2 = 0 , (2) τ 1 > 0 , τ 2 = 0 , (3) τ 1 = 0 , τ 2 > 0 and (4) τ 1 > 0 , τ 2 > 0. Optimal control theory is then applied to the model to study two time-dependent treatment efforts and minimize the infection in citrus and psyllids, while keeping the implementation cost at a minimum. Numerical simulations of the overall systems are implemented in MatLab for demonstration of the theoretical results. [ABSTRACT FROM AUTHOR]

In this paper, a dynamic model given by three-dimensional ordinary differential equations is studied to determine how the dynamics of tumor growth is controlled by some key parameters. By varying the competition coefficient between healthy host cells and tumor cells, a Hopf bifurcation occurs in this system, leading to the creation of a stable limit cycle. Through numerical analysis of the continuity of this limit cycle, we find that the cascade of period-doubling bifurcations leads to the generation of a chaotic attractor. Moreover, the region of attractors is shown in the parameter space. Numerical simulations, bifurcation diagrams, Lyapunov exponent graph and phase portraits permit to highlight the rich and complex phenomena presented by the model. [ABSTRACT FROM AUTHOR]

Bacillus subtilis with competent states absorbs DNA and may improve the growth of bacteria by integrating new genetic material. Therefore, it is important to clarify how the genes interact in the circuit so that cells enter into a competent state or return to a vegetative state. The gene regulatory circuit consists of two positive feedback loops and one negative feedback loop. In this paper, a mathematical model is developed by considering transcription time delays to further study dynamic behavior of the B. subtilis competent gene regulatory network. Combined with theoretical calculation and numerical simulation, it is verified that the time delay in indirect transcription inhibition indeed has the effect of inducing the periodic oscillation of the B. subtilis competent system. In addition, some important chemical reaction rates can also regulate system dynamic behavior. However, under the control of time delay, the effects of the important chemical reaction rates have changed significantly. In particular, the time delay can advance critical value of the important chemical reaction rates where vibration occurs and can also weaken or even eliminate the effect of the important chemical reaction rates. These results will help us to analyze the competent state of B. subtilis. [ABSTRACT FROM AUTHOR]

In this paper, we propose a novel fractional-order proportional-derivative (PD) strategy to achieve the control of bifurcation of a fractional-order gene regulatory model with delays. The stability theory of fractional differential equations proved that with delays, some explicit conditions for the local asymptotical stability and Hopf bifurcation are given for the controlled fractional-order genetic model. It is demonstrated that the fractional-order gene regulatory model becomes controllable by adjusting the control gain parameters. In addition, the effect of fractional-order parameter on the dynamical behaviors is shown. Finally, numerical simulations are carried out to testify the validity of the main results and the availability of the fractional-order PD controller. [ABSTRACT FROM AUTHOR]

In this paper, we study the effects of the nonlocal competition and double Allee effect in prey on a diffusive predator–prey model. We investigate the local stability of coexistence equilibrium in the predator–prey model by analyzing the eigenvalue spectrum. We study the consequence of double Allee effect on the prey population. Also, we discuss the existence of Hopf bifurcation under different parameters by using the gestation time delay of predators as a bifurcation parameter and analyzing the distribution of eigenvalues. By utilizing the normal form method and center manifold theorem, we have given some conditions that could determine the direction of Hopf bifurcation and the stability of the bifurcating periodic solutions. Through our research, we obtain that the double Allee effect can affect the coexistence of prey and predator and induce periodic oscillations of the densities of prey and predator. In addition, the nonlocal competition can also affect the stability and homogeneity of the solutions, but may receive the consequences of the Allee effect as well as time delay. In the numerical simulation part, we further demonstrate the correctness of this conclusion by comparison. [ABSTRACT FROM AUTHOR]

A nonlinear dynamical model is developed in this paper that depicts interactions among vultures, human, animals and their carcasses. Diseases such as plague, anthrax and rabies are spreading due to the cascade impact caused by the catastrophic drop in the vulture population, particularly in Africa and Asia. The built model is theoretically studied using qualitative differential-equation theory to demonstrate the system’s rich dynamical features, which are critical for maintaining the ecosystem’s equilibrium. According to the qualitative findings, depending on the parameter combinations, the system not only displays stability of many equilibrium states but also experiences transcritical and Hopf bifurcations. By keeping an eye on the variables causing the decline of the vulture population, the model’s outputs may assist in maintaining balance with the prevention of the spread of disease through carcasses. Hopf-bifurcation results in the bifurcation of the limit cycle through the threshold, supporting the idea that interactions between humans and vultures may also be periodic. [ABSTRACT FROM AUTHOR]

In this paper, we introduce spatial memory into a predator–prey model with herd behavior. Taking memory-based diffusion coefficient and average memory period of predators as control parameters, we obtain the stable conditions of the positive equilibrium of system and prove the existence of Hopf bifurcation. In addition, a double Hopf bifurcation occurs at the intersection of the nonhomogeneous Hopf bifurcation curves, and a spatially nonhomogeneous quasi-periodic pattern can be observed near the double Hopf bifurcation point by numerical simulation. [ABSTRACT FROM AUTHOR]

In this paper, a delayed diffusive predator–prey model with fear effect under Neumann boundary conditions is considered. For the system without diffusion and delay, the conditions for the existence and local stability of equilibria are obtained by analyzing the eigenvalues. Then, the instability induced by diffusion and delay-diffusion of the positive constant stationary solutions are discussed, respectively. Moreover, the regions of instability and pattern formation can be achieved with respect to diffusion and delay coefficients. Furthermore, the existence and direction of Hopf bifurcation and the properties of the homogeneous/nonhomogeneous bifurcated periodic solutions are driven by using the center manifold theorem and the normal form theory. Finally, some numerical simulations are carried out to verify the theoretical results. [ABSTRACT FROM AUTHOR]

Understanding the dynamical mechanism of the host-parasite interactions is one of important issues on host-parasite association. In this paper, we formulate a three-dimensional host-macroparasite system to describe the host-parasite interactions, which includes the logistic growth rate of host population, the important free-living stage and the host fecundity reduction due to parasite infection. The purpose of the paper is to investigate the asymptotical behavior of the system. By using the properties of the solution to non-autonomous linear system, the basic production number is proved to be a threshold which determines the outcome of the parasites. If , the parasite will eventually die out, and if the parasite will be uniformly persistent. Hopf bifurcation of the system is further studied, and sufficient conditions for the Hopf bifurcation are obtained. By using the singular perturbation techniques, the system is separated into two time scales with a faster time scale for the free-living infective particles and a slower time scale for the population dynamics of host and parasite, and then a complete analysis of the dynamics on the slow manifold is conducted. The theoretical results show that the level of aggregation of parasites within host may influence the persistence and stability of the system. [ABSTRACT FROM AUTHOR]

In this paper, an eco-economic model with harvesting on biological population is established, which takes the form of a differential-algebra system. The impact of the economic profit from harvesting upon the dynamics of the model is studied. By using a suitable parameterization for the differential-algebra system, we derive an equivalent parameterized system which gives the stability results for the positive equilibrium point of our model. Moreover, based on the parameterized system as well as the approaches of normal form and formal series, the conditions on the Hopf bifurcation and the stability of center are obtained. Several numerical simulations for demonstrating the theoretical results are also presented. Lastly, according to the dynamical analysis, we provide a threshold value for the economic profit, which can maintain the sustainable development of our eco-economic system. [ABSTRACT FROM AUTHOR]

In this paper, a mathematical model to study the impact of Twitter in controlling infectious disease is proposed. The model includes the dynamics of “tweets” which may enhance awareness of the disease and cause behavioral changes among the public, thus reducing the transmission of the disease. Furthermore, the model is improved by introducing a time delay between the outbreak of disease and the release of Twitter messages. The basic reproduction number and the conditions for the stability of the equilibria are derived. It is shown that the system undergoes Hopf bifurcation when time delay is increased. Finally, numerical simulations are given to verify the analytical results. [ABSTRACT FROM AUTHOR]

In this paper, we propose a delayed prey-predator-scavenger system with fear effect and linear harvesting. First, we discuss the existence and stability of all possible equilibria. Next, we investigate the existence of Hopf bifurcation of the delayed system by regarding the gestation period of the scavenger as a bifurcation parameter. Furthermore, we obtain the direction of Hopf bifurcation and the stability of bifurcating periodic solutions by using the normal form theory and the central manifold theorem. In addition, we give the optimal harvesting strategy of the delayed system based on Pontryagin's maximum principle with delay. Finally, some numerical simulations are carried out to verify our theoretical results. [ABSTRACT FROM AUTHOR]

In this paper, we study the Hopf bifurcation of predator–prey system with two delays and disease transmission. Furthermore, the global existence of bifurcated periodic solution was studied, the influence of disease transmission is given. At last, some simulations are given to support our result. [ABSTRACT FROM AUTHOR]

In this paper, a fractional-order delayed SIQR model with nonlinear incidence rate is investigated. Two time delays are incorporated in the model to describe the incubation period and the time caused by the healing cycle. By analyzing the associated characteristic equations, the stability of the endemic equilibrium and the existence of Hopf bifurcation are obtained in three different cases. Besides, the critical values of time delays at which a Hopf bifurcation occurs are obtained, and the influence of the fractional order on the dynamics behavior of the system is also investigated. Numerically, it has been shown that when the endemic equilibrium is locally stable, the convergence rate of the system becomes slower with the increase of the fractional order. Besides, our studies also imply that the decline of the fractional order may convert a oscillatory system into a stable one. Furthermore, we find in all these three cases, the bifurcation values are very sensitive to the change of the fractional order, and they decrease with the increase of the order, which means the Hopf bifurcation gradually occurs in advance. [ABSTRACT FROM AUTHOR]

Biological experiments clarify that p53-Mdm2 module is the core of tumor network and p53 oscillation plays an important role in determining the tumor cell fate. In this paper, we investigate the effect of time delay on the oscillatory behavior induced by Hopf bifurcation in p53-Mdm2 system. First, the stability of the unique positive equilibrium point and the existence of Hopf bifurcation are investigated by using the time delay as the bifurcation parameter and by applying the bifurcation theory. Second, the explicit criteria determining the direction of Hopf bifurcation and the stability of bifurcating periodic solutions are developed based on the normal form theory and the center manifold theorem. In addition, the combination of numerical simulation results and theoretical calculation results indicates that time delays in p53-Mdm2 system are critical for p53 oscillations. The results may help us to better understand the biological functions of p53 pathway and provide clues for treatment of cancer. [ABSTRACT FROM AUTHOR]

In this paper, we study a delayed viral infection model with cellular infection and full logistic proliferations for both healthy and infected cells. The global asymptotic stabilities of the equilibria are studied by constructing Lyapunov functionals. Moreover, we investigated the existence of Hopf bifurcation at the infected equilibrium by regarding the possible combination of the two delays as bifurcation parameters. The results show that time delays may destabilize the infected equilibrium and lead to Hopf bifurcation. Finally, numerical simulations are carried out to illustrate the main results and explore the dynamics including Hopf bifurcation and stability switches. [ABSTRACT FROM AUTHOR]

In this paper, we have analyzed a tri-trophic food chain model consisting of phytoplankton, zooplankton and fish population in an aquatic environment. Here, the pelagic water column is divided into two layers namely, the upper layer and the lower layer. The zooplankton population makes a diel vertical migration (DVM) from lower portion to upper portion and vice-versa to trade-off between food source and fear from predator (Fish). Here, mathematical model has been developed and analyzed in a rigorous way. Apart from routine calculations like boundedness and positivity of the solution, local stability of the equilibrium points, we performed Hopf bifurcation analysis of the interior equilibrium point of our model system in a systematic way. It is observed that the migratory behavior of zooplankton plays a crucial role in the dynamics of the model system. Both the upward and downward migration rates of DVM leads the system into Hopf bifurcation. The upward migration rate of zooplankton deteriorates the stable coexistence of all the species in the system, whereas the downward migration rate enhance the stability of the system. Further, we analyze the non-autonomous version of the system to capture seasonal effect of environmental variations. We have shown that under certain parametric restrictions periodic coexistence of all the species of our system is possible. Finally, extensive numerical simulation has been performed to support our analytical findings. [ABSTRACT FROM AUTHOR]

In this paper, we construct a mathematical model to investigate the interaction between the tumor cells, the immune cells and the helper T cells (HTCs). We perform mathematical analysis to reveal the stability of the equilibria of the model. In our model, the HTCs are stimulated by the identification of the presence of tumor antigens. Our investigation implies that the presence of tumor antigens may inhibit the existence of high steady state of tumor cells, which leads to the elimination of the bistable behavior of the tumor-immune system, i.e. the equilibrium corresponding to the high steady state of tumor cells is destabilized. Choosing immune intensity c as bifurcation parameter, there exists saddle-node bifurcation. Besides, there exists a critical value c ∗ , at which a Hopf bifurcation occurs. The stability and direction of Hopf bifurcation are discussed. [ABSTRACT FROM AUTHOR]

In this paper, an eco-epidemiological model with time delay representing the gestation period of the predator is investigated. In the model, it is assumed that the predator population suffers a transmissible disease and the infected predators may recover from the disease and become susceptible again. By analyzing corresponding characteristic equations, the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the disease-free and coexistence equilibria are established, respectively. By means of Lyapunov functionals and LaSalle's invariance principle, sufficient conditions are obtained for the global stability of the coexistence equilibrium, the disease-free equilibrium and the predator-extinct equilibrium of the system, respectively. [ABSTRACT FROM AUTHOR]

In this paper, a delayed diffusive phytoplankton-zooplankton model with Beddington–DeAngelis functional response and toxins is investigated. Existence of equilibria of the system are solved. The global asymptotic stability of the zooplankton-free equilibrium is obtained. The local stability of the coexistent equilibrium and existence of Hopf bifurcation are discussed. In addition, the properties of the Hopf bifurcation are studied based on the center manifold and normal form theory for partial differential equations. Finally, some numerical simulations are also carried out to confirm our theoretical analysis. [ABSTRACT FROM AUTHOR]

In this paper, a model with time delay describing biodegradation of Microcystins (MCs) is investigated. Firstly, the stability of the positive equilibrium and the existence of Hopf bifurcations are obtained. Furthermore, an explicit algorithm for determining the direction and the stability of the bifurcating periodic solutions is derived by using the normal form theory and center manifold argument. Finally, some numerical simulations are carried out to illustrate the applications of the results. [ABSTRACT FROM AUTHOR]

In this paper, a delayed mathematical model was developed based on experimental data to understand how the time delays required for transcription and translation in Mdm2 gene expression affect the kinetic behavior of the p53-Mdm2 network. Taking the time delays as the main research parameters, the stability of the system at the positive equilibrium was studied by using the theoretical method of delay differential equation. We found that such delays can induce oscillations by undergoing a supercritical Hopf bifurcation. Then, we used the normal form theory and the center manifold reduction to study the direction and stability of the bifurcation in detail. Furthermore, we also studied the effects of the length of time delays and the model parameters by numerical simulations. We found that time delays in Mdm2 synthesis are required for p53 oscillations and the length of such delays can determine the amplitude and period of the oscillations. In addition, the model parameters can also change the stability of the system. These results illustrate that the repair process after DNA damage can be regulated by varying time delays and the model parameters. [ABSTRACT FROM AUTHOR]

In this paper, a human immunodeficiency virus (HIV) infection model with both the types of immune responses, the antibody and the killer cell immune responses has been introduced. The model has been made more logical by including two delays in the activation of both the immune responses, along with the combination drug therapy. The inclusion of both the delayed immune responses provides a greater understanding of long-term dynamics of the disease. The dependence of the stability of the steady states of the model on the reproduction number R 0 has been explored through stability theory. Moreover, the global stability analysis of the infection-free steady state and the infected steady state has been proved with respect to R 0 . The bifurcation analysis of the infected steady state with respect to both delays has been performed. Numerical simulations have been carried out to justify the results proved. This model is capable of explaining the long-term dynamics of HIV infection to a greater extent than that of the existing model as it captures some basic parameters involved in the system such as immunological delay and immune response. Similarly, the model also explains the basic understanding of the disease dynamics as a result of activation of the immune response toward the virus. [ABSTRACT FROM AUTHOR]

In this paper, we propose and analyze a three-species predator-prey system in the presence of additional food for top predator. It is assumed that the middle predator is acting as a prey as well as a predator and the top predator consumes both prey as well as middle predator. It is also considered that a constant amount of additional food for top predator exists in the ecosystem. The effects of harvesting of top predator are investigated. The existence and stability conditions of the equilibria have been discussed analytically. The Hopf bifurcation analysis of the system with respect to predation rate of prey to the top predator and the harvesting effort have been analyzed both analytically and numerically. Pontryagin's maximum principle is used to determine the optimal harvesting of top predator population to maximize the discounted net revenue. From our analysis, it is seen that the additional food has a significant impact to prevent the extinction risk of top predator population and also to increase revenue collection. Finally, some numerical results have been given in support of our analytical findings. [ABSTRACT FROM AUTHOR]

In this paper, a diffusive predator-prey system with additional food and intra-specific competition among predators subject to Neumann boundary condition is investigated. For non-delay system, global stability, Turing instability and Hopf bifurcation are studied. For delay system, instability and Hopf bifurcation induced by time delay and global stability of boundary equilibrium are discussed. By the theory of normal form and center manifold method, the conditions for determining the bifurcation direction and the stability of the bifurcating periodic solution are derived. [ABSTRACT FROM AUTHOR]