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Your search keyword '"Bordignon Claudio"' showing total 10 results
Start Over Author "Bordignon Claudio" Journal international journal of cancer
10 results on '"Bordignon Claudio"'

1. Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes

Author

Russo, Vincenzo, Pilla, Lorenzo, Lunghi, Francesca, Crocchiolo, Roberto, Greco, Raffaella, Ciceri, Fabio, Maggioni, Daniela, Fontana, Raffaella, Mukenge, Sylvain, Rivoltini, Licia, Rigamonti, Gianluigi, Mercuri, Santo Raffaele, Nicoletti, Roberto, Maschio, Alessandro Del, Gianolli, Luigi, Fazio, Ferruccio, Marchianò, Alfonso, Florio, Annabella Di, Maio, Michele, Salomoni, Monica, Gallo-Stampino, Corrado, Fiacco, Matteo Del, Lambiase, Antonio, Coulie, Pierre G., Patuzzo, Roberto, Parmiani, Giorgio, Traversari, Catia, Bordignon, Claudio, Santinami, Mario, and Bregni, Marco

Published
2013
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2. Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes

Author

Russo, Vincenzo, primary, Pilla, Lorenzo, additional, Lunghi, Francesca, additional, Crocchiolo, Roberto, additional, Greco, Raffaella, additional, Ciceri, Fabio, additional, Maggioni, Daniela, additional, Fontana, Raffaella, additional, Mukenge, Sylvain, additional, Rivoltini, Licia, additional, Rigamonti, Gianluigi, additional, Mercuri, Santo Raffaele, additional, Nicoletti, Roberto, additional, Maschio, Alessandro Del, additional, Gianolli, Luigi, additional, Fazio, Ferruccio, additional, Marchianò, Alfonso, additional, Florio, Annabella Di, additional, Maio, Michele, additional, Salomoni, Monica, additional, Gallo-Stampino, Corrado, additional, Fiacco, Matteo Del, additional, Lambiase, Antonio, additional, Coulie, Pierre G., additional, Patuzzo, Roberto, additional, Parmiani, Giorgio, additional, Traversari, Catia, additional, Bordignon, Claudio, additional, Santinami, Mario, additional, and Bregni, Marco, additional

Published
2012
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3. High homogeneity of MAGE, BAGE, GAGE, Tyrosinase and Melan-A/MART-1 gene expression in clusters of multiple simultaneous metastases of human melanoma: Implications for protocol design of therapeutic antigen-specific vaccination strategies

Author

Dalerba, Piero, primary, Ricci, Axel, additional, Russo, Vincenzo, additional, Rigatti, Donata, additional, Nicotra, Maria Rita, additional, Mottolese, Marcella, additional, Bordignon, Claudio, additional, Natali, Pier Giorgio, additional, and Traversari, Catia, additional

Published
1998
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9. Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes

Author

Francesca Lunghi, Raffaella Greco, Vincenzo Russo, Annabella Di Florio, Corrado Gallo-Stampino, Giorgio Parmiani, Roberto Nicoletti, Santo Raffaele Mercuri, Monica Salomoni, Ferruccio Fazio, Pierre Coulie, Luigi Gianolli, Daniela Maggioni, Gianluigi Rigamonti, Raffaella Fontana, Roberto Crocchiolo, Matteo Del Fiacco, Lorenzo Pilla, Licia Rivoltini, Mario Santinami, Fabio Ciceri, Sylvain Mukenge, Catia Traversari, Roberto Patuzzo, Michele Maio, Marco Bregni, Claudio Bordignon, Antonio Lambiase, Alfonso Marchianò, Alessandro Del Maschio, Russo, V, Pilla, L, Lunghi, F, Crocchiolo, R, Greco, R, Ciceri, Fabio, Maggioni, D, Fontana, R, Mukenge, S, Rivoltini, L, Rigamonti, G, Mercuri, Sr, Nicoletti, R, DEL MASCHIO, Alessandro, Gianolli, L, Fazio, F, Marchiano, A, Di Florio, A, Maio, M, Salomoni, M, Gallo-stampino, C, Del Fiacco, M, Lambiase, A, Coulie, Pg, Patuzzo, R, Parmiani, G, Traversari, C, Bordignon, Claudio, Santinami, M, and Bregni, M.

Subjects
Adult, Male, Cancer Research, Lung Neoplasms, Skin Neoplasms, Active immunotherapy, T cell, T-Lymphocytes, Bone Neoplasms, Cancer Vaccines, Thymidine Kinase, Immune system, Clinical Trials, Phase II as Topic, Antigen, Antigens, Neoplasm, Medicine, Humans, Hypersensitivity, Delayed, Melanoma, Aged, Neoplasm Staging, business.industry, Liver Neoplasms, antigen-specific immune responses, Cancer, Genetic Therapy, Middle Aged, medicine.disease, Tumor antigen, Neoplasm Proteins, Vaccination, medicine.anatomical_structure, Oncology, Immunology, Female, business, Follow-Up Studies
Abstract

Cancer vaccines have recently been shown to induce some clinical benefits. The relationship between clinical activity and anti-vaccine T cell responses is somewhat controversial. Indeed, in many trials it has been documented that the induction of vaccine-specific T cells exceeds the clinical responses observed. Here, we evaluate immunological and clinical responses in 23 MAGE-A3+ melanoma patients treated with autologous lymphocytes genetically engineered to express the tumor antigen MAGE-A3 and the viral gene product thymidine kinase of the herpes simplex virus (HSV-TK). HSV-TK was used as safety system in case of adverse events and as tracer antigen to monitor the immune competence of treated patients. The increase of anti-TK and anti-MAGE-A3 T-cells after vaccination was observed in 90 and 27% of patients, respectively. Among 19 patients with measurable disease, we observed a disease control rate of 26.3%, with one objective clinical response, and four durable, stable diseases. Three patients out of five with no evidence of disease (NED) at the time of vaccination remained NED after 73+, 70+ and 50+ months. Notably, we report that only patients experiencing MAGE-A3-specific immune responses showed a clinical benefit. Additionally, we report that responder and non-responder patients activate and expand T cells against the tracer antigen TK in a similar way, suggesting that local rather than systemic immune suppression might be involved in limiting clinically relevant antitumor immune responses. OI bregni, marco/0000-0002-3789-1199

Published
2012

10. Characterization of antigenic peptide epitopes by reverse immunology: induction of cytotoxic T lymphocytes specific for exogenous peptide only

Author

Claudio Bordignon, Peter van Endert, Silvia Tanzarella, Katharina Fleischhauer, Catia Traversari, Tanzarella, S., Fleischhauer, K., van Endert, P., Bordignon, Claudio, and C., Traversari

Subjects
chemistry.chemical_classification, Cytotoxicity, Immunologic, Cancer Research, Chemistry, Peptide, CD8-Positive T-Lymphocytes, Epitope, Neoplasm Proteins, Oncology, Antigens, Neoplasm, Immunology, Tumor Cells, Cultured, Cytotoxic T cell, Humans, Peptides, Antigenic peptide, Melanoma, Cells, Cultured, T-Lymphocytes, Cytotoxic
Published
1997

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