5 results on '"Setiawan, V Wendy"'
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2. Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer
- Author
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Kho, Pik‐Fang, primary, Amant, Frederic, additional, Annibali, Daniela, additional, Ashton, Katie, additional, Attia, John, additional, Auer, Paul L., additional, Beckmann, Matthias W., additional, Black, Amanda, additional, Brinton, Louise, additional, Buchanan, Daniel D., additional, Chanock, Stephen J., additional, Chen, Chu, additional, Chen, Maxine M., additional, Cheng, Timothy H. T., additional, Cook, Linda S., additional, Crous‐Bous, Marta, additional, Czene, Kamila, additional, De Vivo, Immaculata, additional, Dennis, Joe, additional, Dörk, Thilo, additional, Dowdy, Sean C., additional, Dunning, Alison M., additional, Dürst, Matthias, additional, Easton, Douglas F., additional, Ekici, Arif B., additional, Fasching, Peter A., additional, Fridley, Brooke L., additional, Friedenreich, Christine M., additional, García‐Closas, Montserrat, additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Goode, Ellen L., additional, Gorman, Maggie, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hankinson, Susan E., additional, Hein, Alexander, additional, Hillemanns, Peter, additional, Hodgson, Shirley, additional, Hoivik, Erling A., additional, Holliday, Elizabeth G., additional, Hunter, David J., additional, Jones, Angela, additional, Kraft, Peter, additional, Krakstad, Camilla, additional, Lambrechts, Diether, additional, Le Marchand, Loic, additional, Liang, Xiaolin, additional, Lindblom, Annika, additional, Lissowska, Jolanta, additional, Long, Jirong, additional, Lu, Lingeng, additional, Magliocco, Anthony M., additional, Martin, Lynn, additional, McEvoy, Mark, additional, Milne, Roger L., additional, Mints, Miriam, additional, Nassir, Rami, additional, Otton, Geoffrey, additional, Palles, Claire, additional, Pooler, Loreall, additional, Proietto, Tony, additional, Rebbeck, Timothy R., additional, Renner, Stefan P., additional, Risch, Harvey A., additional, Rübner, Matthias, additional, Runnebaum, Ingo, additional, Sacerdote, Carlotta, additional, Sarto, Gloria E., additional, Schumacher, Fredrick, additional, Scott, Rodney J., additional, Setiawan, V. Wendy, additional, Shah, Mitul, additional, Sheng, Xin, additional, Shu, Xiao‐Ou, additional, Southey, Melissa C., additional, Tham, Emma, additional, Tomlinson, Ian, additional, Trovik, Jone, additional, Turman, Constance, additional, Tyrer, Jonathan P., additional, Van Den Berg, David, additional, Wang, Zhaoming, additional, Wentzensen, Nicolas, additional, Xia, Lucy, additional, Xiang, Yong‐Bing, additional, Yang, Hannah P., additional, Yu, Herbert, additional, Zheng, Wei, additional, Webb, Penelope M., additional, Thompson, Deborah J., additional, Spurdle, Amanda B., additional, Glubb, Dylan M., additional, and O'Mara, Tracy A., additional
- Published
- 2020
- Full Text
- View/download PDF
3. Racial/ethnic differences in postmenopausal breast cancer risk by hormone receptor status: The multiethnic cohort study.
- Author
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Sarink, Danja, White, Kami K., Loo, Lenora W.M., Wu, Anna H., Wilkens, Lynne R., Le Marchand, Loïc, Park, Song‐Yi, Setiawan, V. Wendy, and Merritt, Melissa A.
- Subjects
BREAST cancer ,HORMONE receptor positive breast cancer ,DISEASE risk factors ,ETHNIC differences ,HORMONE receptors - Abstract
There are racial/ethnic differences in the incidence of hormone receptor positive and negative breast cancer. To understand why these differences exist, we investigated associations between hormone‐related factors and breast cancer risk by race/ethnicity in the Multiethnic Cohort (MEC) Study. Among 81 511 MEC participants (Native Hawaiian, Japanese American, Latina, African American and White women), 3806 estrogen receptor positive (ER+) and 828 ER− incident invasive breast cancers were diagnosed during a median of 21 years of follow‐up. We used Cox proportional hazards regression models to calculate associations between race/ethnicity and breast cancer risk, and associations between hormone‐related factors and breast cancer risk by race/ethnicity. Relative to White women, ER+ breast cancer risk was higher in Native Hawaiians and lower in Latinas and African Americans; ER− disease risk was higher in African Americans. We observed interaction with race/ethnicity in associations between oral contraceptive use (OC; Pint.03) and body mass index (BMI; Pint.05) with ER+ disease risk; ever versus never OC use increased risk only in Latinas and positive associations for obese versus lean BMI were strongest in Japanese Americans. For ER‐ disease risk, associations for OC use, particularly duration of use, were strongest for African Americans (Pint.04). Our study shows that associations of OC use and obesity with ER+ and ER− breast cancer risk differ by race/ethnicity, but established risk factors do not fully explain racial/ethnic differences in risk. Further studies are needed to identify factors to explain observed racial/ethnic differences in breast cancer incidence. What's new? Racial/ethnic differences in hormone receptor positive and negative breast cancer risk are well‐documented; the factors contributing to these differences less so. The authors compared hormone‐related risk factors for breast cancer among a multiethnic population. They identified a number of notable differences in the impact of established risk factors ‐ particularly oral contraceptive use and BMI ‐ between racial/ethnic groups. These results reinforce the need to consider race/ethnicity in breast cancer studies and prevention recommendations. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium
- Author
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Fortner, Renée T., primary, Poole, Elizabeth M., additional, Wentzensen, Nicolas A., additional, Trabert, Britton, additional, White, Emily, additional, Arslan, Alan A., additional, Patel, Alpa V., additional, Setiawan, V. Wendy, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Adami, Hans‐Olov, additional, Black, Amanda, additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Buring, Julie, additional, Clendenen, Tess V., additional, Fournier, Agnès, additional, Fraser, Gary, additional, Gapstur, Susan M., additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Gram, Inger T., additional, Hartge, Patricia, additional, Hoffman‐Bolton, Judith, additional, Idahl, Annika, additional, Kaaks, Rudolf, additional, Kirsh, Victoria A., additional, Knutsen, Synnove, additional, Koh, Woon‐Puay, additional, Lacey, James V., additional, Lee, I‐Min, additional, Lundin, Eva, additional, Merritt, Melissa A., additional, Milne, Roger L., additional, Onland‐Moret, N. Charlotte, additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Rinaldi, Sabina, additional, Robien, Kim, additional, Rohan, Thomas, additional, Sánchez, Maria‐José, additional, Schairer, Catherine, additional, Schouten, Leo J., additional, Tjonneland, Anne, additional, Townsend, Mary K., additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, Brandt, Piet A., additional, Vineis, Paolo, additional, Wilkens, Lynne, additional, Wolk, Alicja, additional, Yang, Hannah P., additional, Zeleniuch‐Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
- Published
- 2019
- Full Text
- View/download PDF
5. Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer.
- Author
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Kho PF, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, Black A, Brinton L, Buchanan DD, Chanock SJ, Chen C, Chen MM, Cheng THT, Cook LS, Crous-Bous M, Czene K, De Vivo I, Dennis J, Dörk T, Dowdy SC, Dunning AM, Dürst M, Easton DF, Ekici AB, Fasching PA, Fridley BL, Friedenreich CM, García-Closas M, Gaudet MM, Giles GG, Goode EL, Gorman M, Haiman CA, Hall P, Hankinson SE, Hein A, Hillemanns P, Hodgson S, Hoivik EA, Holliday EG, Hunter DJ, Jones A, Kraft P, Krakstad C, Lambrechts D, Le Marchand L, Liang X, Lindblom A, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, McEvoy M, Milne RL, Mints M, Nassir R, Otton G, Palles C, Pooler L, Proietto T, Rebbeck TR, Renner SP, Risch HA, Rübner M, Runnebaum I, Sacerdote C, Sarto GE, Schumacher F, Scott RJ, Setiawan VW, Shah M, Sheng X, Shu XO, Southey MC, Tham E, Tomlinson I, Trovik J, Turman C, Tyrer JP, Van Den Berg D, Wang Z, Wentzensen N, Xia L, Xiang YB, Yang HP, Yu H, Zheng W, Webb PM, Thompson DJ, Spurdle AB, Glubb DM, and O'Mara TA
- Subjects
- Case-Control Studies, Cholesterol, HDL genetics, Cholesterol, LDL genetics, Endometrial Neoplasms genetics, Female, Genome-Wide Association Study, Humans, Mendelian Randomization Analysis, Risk, Triglycerides genetics, Cholesterol, HDL blood, Cholesterol, LDL blood, Endometrial Neoplasms blood, Triglycerides blood
- Abstract
Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P < 5 × 10
-8 ) were identified as instrumental variables, and assessed using genome-wide association study data from the Endometrial Cancer Association Consortium (12 906 cases and 108 979 controls) and the Global Lipids Genetic Consortium (n = 188 578). Mendelian randomization analyses found genetically raised LDL cholesterol levels to be associated with lower risks of endometrial cancer of all histologies combined, and of endometrioid and non-endometrioid subtypes. Conversely, higher genetically predicted HDL cholesterol levels were associated with increased risk of non-endometrioid endometrial cancer. After accounting for the potential confounding role of obesity (as measured by genetic variants associated with body mass index), the association between genetically predicted increased LDL cholesterol levels and lower endometrial cancer risk remained significant, especially for non-endometrioid endometrial cancer. There was no evidence to support a role for triglycerides in endometrial cancer development. Our study supports a role for LDL and HDL cholesterol in the development of non-endometrioid endometrial cancer. Further studies are required to understand the mechanisms underlying these findings., (© 2020 Union for International Cancer Control.)- Published
- 2021
- Full Text
- View/download PDF
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