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Abstract: Myeloperoxidase (MPO) is a marker of inflammation that has been suggested to have prognostic role in patients with acute coronary syndrome. We sought to investigate whether day–night variations occur in the concentration of circulating MPO in patients with ST-segment elevation myocardial infarction (STEMI), as this may have practical implications. We assessed 70 consecutive STEMI patients admitted to the Coronary Care Unit and 50 age- and gender-matched apparently healthy control subjects. Blood samples were drawn at 09:00 a.m. (light phase) and 02:00 a.m. (dark phase). MPO was measured using a commercially available ELISA. MPO levels showed no diurnal variations in control subjects. In STEMI group, however, MPO concentration (ng/mL) in the dark phase was significantly higher than that in the light phase (83.30±33.08 vs. 64.10±31.30, p <0.001). The study shows for the first time the existence of diurnal variations in MPO levels in STEMI patients, which indicates the need for standardizing the time of blood sampling for the assessment of this molecule. [ABSTRACT FROM AUTHOR]

Abstract: Background: Results of previous studies have shown that serum neopterin levels are higher in patients with acute myocardial infarction (AMI). However, little is known regarding the prognostic value of neopterin in survivors of AMI. The present study analyzes the prognostic value of neopterin serum concentration and left ventricular ejection fraction in survivors of AMI. Methods: The additional prognostic information provided by neopterin to parameters of left ventricular function in survivors of AMI was investigated through 82 patients with ST-segment elevation. Results: Binary logistic regression analysis identified the following predictors of 6-month cardiac death: Killip class >I at presentation (OR=2.4, 95% CI: 1.2 to 3.8, p =0.001), a reduced ejection fraction (OR=1.9, 95% CI: 1.3 to 2.2, p =0.001), and greater neopterin (OR=1.4, 95% CI: 1.1 to 1.6, p =0.01). Conclusions: Neopterin is associated with mortality, in addition to parameters of ventricular function (Killip class and ejection fraction) in survivors of AMI. [Copyright &y& Elsevier]