Search

Your search keyword '"Bigalke, Boris"' showing total 13 results
Start Over Author "Bigalke, Boris" Journal international journal of cardiology
13 results on '"Bigalke, Boris"'

6. Atrioventricular mechanical coupling and major adverse cardiac events in female patients following acute ST elevation myocardial infarction

Author

Backhaus, Sören J., primary, Kowallick, Johannes T., additional, Stiermaier, Thomas, additional, Lange, Torben, additional, Koschalka, Alexander, additional, Navarra, Jenny-Lou, additional, Uhlig, Johannes, additional, Lotz, Joachim, additional, Kutty, Shelby, additional, Bigalke, Boris, additional, Gutberlet, Matthias, additional, Hasenfuß, Gerd, additional, Thiele, Holger, additional, Eitel, Ingo, additional, and Schuster, Andreas, additional

Published
2020
Full Text
View/download PDF

8. Electrophysiological characterization of scars detected by contrast enhanced magnetic resonance imaging in patients with non-ischemic cardiomyopathy

Author

Seizer, Peter, primary, Zuern, Christine S., additional, Maier, Johannes, additional, Kerst, Gunter, additional, Weig, Hans-Jörg, additional, Gansser, Lisa, additional, Kramer, Ulrich, additional, May, Andreas E., additional, Parade, Uli, additional, Bigalke, Boris, additional, Bauer, Axel, additional, Gawaz, Meinrad, additional, Geisler, Tobias, additional, and Schreieck, Jürgen, additional

Published
2013
Full Text
View/download PDF

9. Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy

Author

Schuster, Andreas, primary, Paul, Matthias, additional, Bettencourt, Nuno, additional, Morton, Geraint, additional, Chiribiri, Amedeo, additional, Ishida, Masaki, additional, Hussain, Shazia, additional, Jogiya, Roy, additional, Kutty, Shelby, additional, Bigalke, Boris, additional, Perera, Divaka, additional, and Nagel, Eike, additional

Published
2013
Full Text
View/download PDF

12. Copeptin as a prognostic factor for major adverse cardiovascular events in patients with coronary artery disease

Author

von Haehling, Stephan, primary, Papassotiriou, Jana, additional, Morgenthaler, Nils G., additional, Hartmann, Oliver, additional, Doehner, Wolfram, additional, Stellos, Konstantinos, additional, Wurster, Thomas, additional, Schuster, Andreas, additional, Nagel, Eike, additional, Gawaz, Meinrad, additional, and Bigalke, Boris, additional

Published
2012
Full Text
View/download PDF

13. PET/CT and MR imaging biomarker of lipid-rich plaques using [64Cu]-labeled scavenger receptor (CD68-Fc).

Author

Bigalke, Boris, Phinikaridou, Alkystis, Andia, Marcelo E., Cooper, Margaret S., Schuster, Andreas, Wurster, Thomas, Onthank, David, Münch, Götz, Blower, Philip, Gawaz, Meinrad, Nagel, Eike, and Botnar, Rene M.

Subjects
*BIOMARKERS, *LIPIDS, *SCAVENGER receptors (Biochemistry), *CD antigens, *LOW density lipoproteins, *MACROPHAGE activation
Abstract

Continued uptake of modified low-density lipoproteins (LDL) by the scavenger receptor, CD68, of activated macrophages is a crucial process in the development of atherosclerotic plaques and leads to the formation of foam cells. Eight-weeks-old male Apolipoprotein E-deficient (ApoE-/-) mice (n=6) were fed a high-fat diet for 12 weeks. C57BL/6J wildtype (WT) mice served as controls (n=6). Positron emission tomography (PET) with an acquisition time of 1800s (NanoPET/CT scanner; Mediso, Hungary & Bioscan, USA) was carried out 24h after intravenous tail vein administration of 50µl 64Cu-CD68-Fc (~20-30µg labeled protein/mouse containing approximately 10-12MBq 64Cu-CD68-Fc per mouse). Three days after PET/CT, all mice received an intravenous administration of 0.2 mmol/kg body weight of a gadolinium-based elastin-binding contrast agent to assess plaque burden and vessel wall remodeling. Two hours after injection, mice were imaged in a 3T clinical MR scanner (Philips Healthcare, Best, NL) using a dedicated single loop surface coil (23mm). Enhanced 64Cu-CD68-Fc uptake was found in the aortic arches of ApoE-/- compared to WT mice (ApoE-/- mice:10.5±1.5Bq/cm³ vs. WT mice: 2.1±0.3Bq/cm³; P=0.002). Higher gadolinium-based elastin-binding contrast agent uptake was also detected in the aortic arch of ApoE-/- compared to WT mice using R¹ maps (R¹=1.47±0.06 s-1 vs. 0.92±0.05 s-1; P <0.001). Radiolabeled scavenger receptor (64Cu-CD68-Fc) may help to target foam cell rich plaques with high content of oxidized LDL. This novel imaging biomarker tool may have potential to identify unstable plaques and for risk stratification. [ABSTRACT FROM AUTHOR]

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results