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Objective: Takotsubo cardiomyopathy, also known as stress-induced cardiomyopathy (SCM) resembles a reversible cardiomyopathy that is characterized by localized wall motion abnormalities in the absence of stenotic coronary vascular disease. Patients typically present with apical ballooning of the left ventricle (LV), however the right ventricle (RV) is also affected in up to 50.0% of patients. Long-term prognosis of classical SCM resembles that of patients after ST elevation myocardial infarction. Data on long-term prognosis of biventricular compared to classical SCM is controversial. The aim of this study was therefore to analyze patients with biventricular SCM regarding in-hospital outcome and long-term prognosis., Materials and Methods: 114 consecutive patients with SCM were retrospectively analyzed. 88 patients presented with classical SCM, 26 patients (22.8%) were diagnosed with biventricular SCM. Follow-up was conducted for a total of 4.4years. Mean age was 67.1years with 83.3% of patients being female. The primary endpoint was a composite of all-cause mortality, recurrence of SCM and re-hospitalization due to heart failure., Results: Although patients with biventricular SCM presented with a tendency towards an increased rate of cardiogenic shock (30.8% vs. 15.9%; p=0.09) and significantly more usage of inotropic support upon hospital admission (34.6% vs. 13.6%; p=0.01), there was no difference concerning the primary endpoint in both groups (50.0% vs. 44.3%; p=0.31). Furthermore, there was no difference in mortality both in-hospital (7.7% vs. 7.9%; p=0.66) and during long-term follow-up (27.3% vs. 23.1%; p=0.46)., Conclusion: Patients with biventricular SCM have the same in-hospital and long-term outcome compared to classical SCM., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

Aims: Dilated cardiomyopathy (DCM) shows a variable disease course and is associated with significant morbidity and mortality. So far, left ventricular function (LVF) is the major determinant for risk stratification. However, since it has shown to be a poor guide to individual outcome, we studied the prognostic value of cardiovascular magnetic resonance imaging (CMR) parameters, late gadolinium enhancement (LGE) and epicardial adipose tissue (EAT)., Methods and Results: 140 patients with DCM underwent late gadolinium enhancement (LGE) CMR. During a median follow-up of 3 years, 22 patients (16%) died and another 51 (36%) were hospitalized due to congestive heart failure (CHF). Female gender and right ventricular ejection fraction (RV-EF) below the median of 38% were independent predictors of all-cause mortality in multivariable analysis. In patients who were hospitalized due to CHF, RV-EF below the median of 38% was the only independent predictor in multivariable analysis. When patients where further stratified according to systolic LV-EF, the prognostic value of RV-EF to predict mortality and cardiac morbidity remained unchanged. Looking at DCM patients who died during follow-up compared to those who were hospitalized due to CHF, the former presented with a higher prevalence of LGE as well as reduced indexed EAT., Conclusion: Female gender, RV-EF and the presence of LGE are of prognostic importance in patients with DCM. Therefore, the present study underlines the role of CMR as an important tool for risk stratification in patients with DCM., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)

To assess cardiovascular magnetic resonance (CMR) findings in Takotsubo cardiomyopathy (TTC), 17 consecutive patients (15 women) with TTC who underwent left heart catheterization and gadolinium-enhanced CMR were evaluated. All patients had an abnormal electrocardiogram consisting of ST-segment elevation (n=8) and/or ST-segment depression (n=4) and/or T-wave inversion (n=14). One patient presented with left-bundle branch block. Left ventricular apical segments were involved in 10 patients (classical TTC), while they were not affected in 7 (variant form). Mean time delay between presentation and CMR was 9+/-7 days (range 3-24 days). CMR demonstrated complete resolution (n=4) or significant improvement of initial WMA in all cases. WMA were confined to basal and mid-ventricular segments (segments 1-12 in the 17-segment model) in the variant form, while they were virtually confined to the mid and apical left ventricle (segments 7-17) in classical TTC. Upon presentation ejection fraction by ventriculography was lower in classical TTC (36+/-7% vs. 58 +/-8%, p=0.0001). However, upon follow up ejection fraction by CMR was not different between classical and variant TTC (49+/-9% vs. 56+/-11%, p=0.23). Delayed hyperenhancement was absent in all but one patient. This finding may help differentiate TTC from entities with similar clinical presentations such as myocarditis and myocardial infarction, as the latter typically exhibits a subendocardial pattern of delayed hyperenhancement while the former usually displays a patchy subepicardial pattern.

Background: Noninvasive testing for suspected coronary artery disease is challenging. We prospectively investigated whether measurements of carotid intima-media thickness in the presence or absence of albuminuria in patients with stable chest pain syndromes can be used as a noninvasive test algorithm for prediction of significant coronary artery disease. Additionally, this algorithm was tested with regard to gender differences., Methods: Consecutive patients (79 men and 72 women) with stable chest pain syndromes and suspected coronary artery disease admitted for coronary angiography were studied. Measurements of intima-media thickness were performed by ultrasound. Urinary albumin excretion was measured in a random urine specimen. A positive test for coronary artery disease was defined as an intima-media thickness >or=1 mm or albuminuria., Results: Sensitivity, specificity and positive likelihood ratio for a combination of intima-media thickness values >or=1 mm or presence of albuminuria to predict coronary artery disease were, respectively, 0.5, 0.73 and 1.27 in men and 0.68, 0.79 and 3.32 in women. Sensitivity, specificity and positive likelihood ratio for exercise ECG were, respectively, 0.54, 0.48 and 1.08 in men and 0.47, 0.45 and 0.8 in women., Conclusions: Intima-media thickness of the common carotid artery or presence of albuminuria are clinically valuable parameters in the noninvasive diagnostic work up of women with stable chest pain syndromes. Their value is limited in men.