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Background Chronic kidney disease is now regarded as a risk factor for cardiovascular disease. The impact of occupational or non-occupational physical activity (PA) on moderate decreases of renal function is uncertain. Objectives We aimed to identify the potential association of PA (occupational and leisure-time) on early decline of estimated glomerular filtration rate (eGFR) and to determine the potential mediating effect of PA on the relationship between eGFR and heart disease. Methods From the PRIME study analyses were conducted in 1058 employed men. Energy expended during leisure, work and commuting was calculated. Linear regression analyses were used to determine the link between types of PA and moderate decrements of eGFR determined with the KDIGO guideline at the baseline assessment. Cox proportional hazards analyses were used to explore the potential effect of PA on the relationship between eGFR and heart disease, ascertained during follow-up over 10years. Results For these employed men, and after adjustment for known confounders of GFR change, more time spent sitting at work was associated with increased risk of moderate decline in kidney function, while carrying objects or being active at work was associated with decreased risk. In contrast, no significant link with leisure PA was apparent. No potential mediating effect of occupational PA was found for the relationship between eGFR and coronary heart disease. Conclusion Occupational PA (potential modifiable factors) could provide a dual role on early impairment of renal function, without influence on the relationship between early decrease of e-GFR and CHD risk.

cardiovascular disease: Emerging opportunities for prevention?☆ Yolande Esquirol ⁎, John Yarnell , Jean Ferrieres , Alun Evans , Jean-Bernard Ruidavets , Aline Wagner , Jean Dallongeville , Dominique Arveiler , Pierre Ducimetiere , Philippe Amouyel , Annie Bingham , Frank Kee d and on behalf of the Prime study a Inserm, UMR1027, Toulouse, F-31073, France b Universite de Toulouse III, UMR1027, Toulouse, F-31073, France c CHU Toulouse, SMPE, F-31059, France d UK Clinical Research Collaboration Centre of Excellence for Public Health, Queen's University Belfast, Belfast, UK e CHU Toulouse, Department of Cardiology B, F-31059, France f Strasbourg MONICA Project, Department of Epidemiology and Public Health, EA 3430, Strasbourg University, 67085 Strasbourg cedex, France g Lille MONICA Project, Inserm UMR744, Lille, France h Institut Pasteur de Lille, Lille, France i Lille Nord de France University, Lille, France j Inserm-Paris XI University, Paul Brousse Hospital, Villejuif, France