1. Gender differences and management of stroke risk of nonvalvular atrial fibrillation in an upper middle-income country: Insights from the CARMEN-AF registry☆
- Author
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Luis Ángel Trujillo Muñoz, Héctor Francisco Fernández Saldaña, Milton E Guevara-Valdivia, Carlos Cantú-Brito, Jorge A. Vázquez-Acosta, Miguel Ángel Negrete Rivera, Alberto Zenón Baños Velasco, José Raúl de los Ríos Ibarra, César Iván Vázquez Serna, José Salvador Lainez Zelaya, José Paz Marcelo Jiménez Cruz, César González Aguilar, Kulio A. Aguilar-Linares, Ulises Rojel Martínez, Juan Carlos Nunez Fragoso, Karim Yarek Juarez Escobar, Vanesa Esperanza Matadamas Carmona, José Luis Novelo Del Valle, José L. Leiva-Pons, Gerardo Pozas-Garza, Marco Antonio Alcocer Gamba, Eddie A. Favela-Pérez, José Manuel Enciso Muñoz, Sadoc Marín Rendon, J. Antonio González-Hermosillo, Yoloxochitl García Jiménez, Carlos Gutiérrez González, Susano Lara Vaca, Enrique Martínez Flores, Laura Reséndiz Barrón, Fernando Flores Silva, Alejandro Lechuga Martín del Campo, Lidia Evangelina Betancourt Hernández, Norberto Matadamas Hernández, Candelaria Mancilla, Manuel Alfonso Baños-González, Humberto Rodríguez Reyes, María Isabel Sánchez Ramírez, Manuel Odín de los Ríos Ibarra, José Fabián Hernández Díaz, Nicolás Reyes Reyes, Luis Gerardo Molina Fernández de Lara, Saúl Flores, Edgar Alfredo Rodríguez Salazar, Samantha Rodríguez Bastidas, Marcos Robledo, Amanda Castelán Ojeda, Miguel Ernesto Beltrán Gámez, Carmen Summerson Lama, Luis Delgado Leal, Jorge Gómez Flores, José Refugio Ramírez González, Rocío Camacho Casillas, Marco Aurelio Islava Gálvez, Raúl Isaac Márquez, Ramón Miguel Esturau Santaló, Demetrio Kosturakis García, Jorge Carrillo Calvillo, María Sangeado Santos, Reynaldo Magaña Magaña, Mariano Miguel Guerra, and Manlio F. Márquez
- Subjects
lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,APD, Antiplatelet drugs ,DOAC, Direct oral anticoagulants ,Cardiomyopathy ,030204 cardiovascular system & hematology ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,Antithrombotic ,Thromboembolic risk ,AF, Atrial fibrillation ,Medicine ,030212 general & internal medicine ,Stroke ,Mexico ,Antithrombotic therapy ,Original Paper ,business.industry ,ATT, Antithrombotic therapy ,Gender ,Atrial fibrillation ,medicine.disease ,Obstructive sleep apnea ,lcsh:RC666-701 ,VKA, Vitamin K antagonists ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Atrial Fibrillation (AF) is associated with an increased risk of stroke and systemic embolism. Several studies have suggested that female AF patients could have a greater risk for stroke. There is scarce information about clinical characteristics and use of antithrombotic therapies in Latin American patients with nonvalvular AF. Objective: To describe the gender differences in clinical characteristics, thromboembolic risk, and antithrombotic therapy of patients with nonvalvular AF recruited in Mexico, an upper middle-income country, into the prospective national CARMEN-AF Registry. Methods: A total of 1423 consecutive patients, with at least one thromboembolic risk factor were enrolled in CARMEN-AF Registry during a three-year period (2014–2017). They were categorized according to Gender. Results: Overall, 48.6% were women, mean age 70 ± 12 years. Diabetes, smoking, alcoholism, non-ischemic cardiomyopathy, coronary artery disease, and obstructive sleep apnea were higher in men. Most women were found with paroxysmal AF (40.6%), and most men with permanent AF (44.0%). No gender differences were found in the use of vitamin K antagonists (VKA) (30.5% in women vs. 28.0% in men). No gender differences were found in the use of direct oral anticoagulants (DOAC) (33.8% women vs 35.4% men). Conclusions: CARMEN-AF Registry demonstrates that in Mexico, regardless of gender, a large proportion of patients remain undertreated. No gender differences were found in the use of VKA or DOAC. Keywords: Atrial fibrillation, Gender, Thromboembolic risk, Antithrombotic therapy, Stroke, Mexico
- Published
- 2019