1. The influence of implantation techniques on lesion oriented-outcomes in Absorb BVS and Xience EES lesions treated in routine clinical practice at complete three year follow-up: AIDA trial QCA substudy
- Author
-
Yohei Sotomi, Deborah N. Kalkman, E. Karin Arkenbout, Jan J. Piek, Martina Nassif, Taku Asano, Ruben Y.G. Tijssen, Jan G.P. Tijssen, Carlos Collet, Ply Chichareon, Rodrigo Modolo, Patrick W. Serruys, Auke P.J.D. Weevers, Joanna J. Wykrzykowska, Robbert J. de Winter, Yoshinobu Onuma, Sjoerd H. Hofma, Norihiro Kogame, José P.S. Henriques, Laura S.M. Kerkmeijer, Yuki Katagiri, Kuniaki Takahashi, René J. van der Schaaf, Robin P. Kraak, Graduate School, Cardiology, ACS - Atherosclerosis & ischemic syndromes, ACS - Heart failure & arrhythmias, and ACS - Microcirculation more...
- Subjects
medicine.medical_specialty ,Time Factors ,Myocardial Infarction ,Target vessel ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Coronary Angiography ,Prosthesis Design ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Quantitative coronary angiography ,Absorbable Implants ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Routine clinical practice ,030212 general & internal medicine ,Myocardial infarction ,Angioplasty, Balloon, Coronary ,Pump thrombosis ,Target lesion revascularization ,business.industry ,Composite outcomes ,Drug-Eluting Stents ,Thrombosis ,medicine.disease ,Drug eluting stents ,Coronary Vessels ,Current analysis ,Treatment Outcome ,Bioresorbable scaffolds ,Radiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
It has been hypothesized that dedicated optimized Absorb BVS implantation techniques might mitigate the risk of adverse events such as target vessel failure and device thrombosis. In this explorative AIDA trial QCA substudy, we sought to investigate the influence of implantation techniques on lesion-oriented outcomes in both the Absorb BVS and Xience EES arm at complete 3-year follow-up. The current analysis includes 2152 study lesions treated with at least one study device, of which the baseline angiogram was suited for offline QCA analysis, including Dmax analysis. The lesion-oriented composite outcome (LOCE) of this analysis was a composite of definite device thrombosis, target lesion revascularization and target-vessel myocardial infarction. In Absorb BVS, the Lesion-oriented composite endpoint (LOCE) occurred numerically less in correctly QCA sized vessels when compared to incorrectly sized vessels 8.5% (58/696) versus 11.1% (39/358), p = 0.151. In Xience EES, LOCE had occurred more frequently in incorrectly sized devices according to device diameter/RVD matching; 2.2% (4/187) in correctly sized devices versus 7.1% (63/911) in incorrectly sized devices (p = 0.014). In this AIDA trial QCA substudy, rates of LOCE were significantly lower in Xience EES treated lesions in which devices were correctly sized according to the definitions of device diameter/RVD matching. more...
- Published
- 2020