1. Does the extension of the type of hysterectomy contribute to the local control of endometrial cancer?
- Author
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Mikiko Asai-Sato, Aiko Yashiro-Kawano, Haruya Saji, Hiroyuki Shigeta, Emi Ohnuma, Masakazu Kitagawa, Yasuyo Maruyama, Yuka Oi, Yuko Mine, Hanako Taniguchi, Megumi Furugori, Ken Sugiura, Kazumi Kubota, Tatsuya Matsunaga, Reiko Numazaki, Hisamori Kato, Etsuko Miyagi, Keiko Segawa, and Tetsuya Hasegawa
- Subjects
0301 basic medicine ,Adult ,medicine.medical_specialty ,Multivariate analysis ,medicine.medical_treatment ,Urology ,Type of hysterectomy ,Kaplan-Meier Estimate ,Hysterectomy ,03 medical and health sciences ,0302 clinical medicine ,Endometrial cancer ,Surgical oncology ,medicine ,Adjuvant therapy ,Local recurrence ,Humans ,Stage (cooking) ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Hazard ratio ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Confidence interval ,Endometrial Neoplasms ,030104 developmental biology ,Treatment Outcome ,Oncology ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Surgery ,Female ,Original Article ,Neoplasm Recurrence, Local ,business - Abstract
Objective To examine the necessity and sufficiency of different types of hysterectomy for the surgical treatment of endometrial cancer. Methods This was a multicenter collaborative study conducted by 11 institutions. Among patients with stage I–III endometrial cancer who underwent surgery as the initial treatment (only chemotherapy was provided if adjuvant therapy was needed) from 2001 to 2012, we retrospectively examined the type of hysterectomy, clinicopathological factors, recurrence rate over a maximum period of 5 years, and the site of recurrence. The local recurrence rate was examined by univariate and multivariate analyses. Results Among 1335 patients, 982 (73.6%) underwent simple hysterectomy (SH) and 353 (26.4%) underwent modified radical hysterectomy (mRH) and were observed for a mean duration of 51.8 months. No significant difference was observed in the rate of local recurrence between the SH and mRH groups (p = 0.928). In multivariate analysis, clinicopathological factors independently associated with localized recurrence included postmenopausal status [hazard ratio (HR) 5.036, 95% confidence interval (CI) 1.506–16.841, p = 0.009], with stages II (HR 3.337, 95% CI 1.701–6.547, p
- Published
- 2018