Search

Your search keyword '"Aiba, Setsuya"' showing total 13 results
Start Over Author "Aiba, Setsuya" Journal international journal of dermatology
13 results on '"Aiba, Setsuya"'

13. Interferon-alpha is effective for CD4(+), CCR4(-) mycosis fungoides.

Author

Fujimura T, Okuyama R, Watabe A, Hashimoto A, Tagami H, and Aiba S

Subjects
Antineoplastic Agents administration & dosage, CD4-Positive T-Lymphocytes metabolism, Diagnosis, Differential, Erythema etiology, Humans, Injections, Subcutaneous, Interferon-alpha administration & dosage, Male, Middle Aged, Mycosis Fungoides blood, Mycosis Fungoides complications, Mycosis Fungoides metabolism, Mycosis Fungoides pathology, Receptors, CCR4, Receptors, Chemokine metabolism, Antineoplastic Agents therapeutic use, Interferon-alpha therapeutic use, Mycosis Fungoides diagnosis, Mycosis Fungoides drug therapy
Abstract

Mycosis fungoides (MF), a cutaneous T-cell lymphoma, is usually characterized by cell features of T-helper-2 (Th2) lymphocytes. MF has recently been reported to show increased CCR4 expression, a chemokine receptor specifically expressed in Th2. Previously, we have reported the effectiveness of interferon-gamma (IFN-gamma) for the treatment of CCR4(+) MF. In this report, we describe two cases of CD4(+), CCR4(-) MF successfully treated with IFN-alpha, but not IFN-gamma. Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN-alpha, but not IFN-gamma, for CCR4- MF.

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results