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Positive anti-Treponemal immunohistochemistry (original magnification ×200) gl Discussion Lues maligna (malignant syphilis) is a distinct form of secondary syphilis characterized by a widespread papulopustular eruption that rapidly transforms into necrotic, sharply marginated ulcers with hemorrhagic crusts organized in rupioid layers. Histopathological features of lues maligna may be similar to the common form of secondary syphilis, yet the infiltrates are more severe and more granulomatous. 2 Don PC, Rubinstein R, Christie S. Malignant syphilis (lues maligna) and concurrent infection with HIV. [Extracted from the article]