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Background: Inflammation in impaired diabetic wound healing has been described as caught in a persistent inflammatory state. Accumulation of advanced glycation end products (AGEs) is closely relevant to impaired diabetic wound. Recent studies identified that blockade of AGEs-RAGE increased neovascularization and granulation tissue formation to improving diabetic wound healing. Objective: This study aimed to evaluate the correlation among the pathogenic effects of AGEs-RAGE, persistent abnormal inflammatory inflammation stage, and impaired wound healing on diabetes. Methods: Authors examined the levels of inflammatory factor secretion and inflammatory leukocytes infiltration and the connection with AGEs-RAGE interaction on diabetic mice. Results: Blockade of AGEs-RAGE improved essential secretion of inflammatory factors and infiltration of inflammatory leukocytes in the early inflammatory stage. Furthermore, it also improved the clean of neutrophils by macrophages. Conclusions: In summary, these findings suggest that rather than a hyper-inflammatory state, diabetic wounds are lack of an essential inflammatory response in the early phase, thus may induce a paradoxical and persistent inflammation state, and AGEs-RAGE play a vital role in these pathogenic progresses. [ABSTRACT FROM AUTHOR]