This article proposes a direct approach for the prediction of inverter efficiency using MATLAB/Simulink, instead of an indirect loss calculation approach based on analytical models. In analytical approach, efficiency is obtained by calculating individual losses separately, such as switching losses, conduction losses and harmonic losses using analytical models. However, this approach requires accurate analytical models and complicated calculations, due to the variation in the switching frequency, switching transient and modulation techniques. In the proposed approach, the actual waveform of the inverter system is directly generated using MATLAB/Simulink. The instantaneous voltage and current waveform including switching transients are generated. Thus, the proposed approach is very simple and convenient for efficiency prediction. The proposed approach also works for any system parameters or control methods, such as various pulse-width modulation (PWM) techniques, different switching frequencies, switching devices and load types. The proposed approach can be adopted for the efficiency prediction of any switching strategies and any types of inverters such as neutral-point-clamped (NPC) inverters, H bridge inverters and H5 topology, since the topologies are modelled as circuits in the MATLAB/Simulink program and no analytical model is required for the proposed approach. Furthermore, the proposed approach can provide operation techniques and conditions such as PWM techniques and switching frequency that offer high efficiency. In this article, inverter performance is evaluated for various PWM techniques and switching frequencies. The PWM technique and switching frequency that offer high efficiency is obtained. Finally, the proposed approach is verified by experimental results. [ABSTRACT FROM PUBLISHER]