1. Association between maternal exposure to arsenic by drinking water during pregnancy and risk of preterm birth: a systematic review and meta-analysis.
- Author
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Margiana, Ria, Hamoud Alshahrani, Shadia, Kayumova, Dilrabo, Hussien Radie Alawadi, Ahmed, Hjazi, Ahmed, Alsalamy, Ali, Qasim, Qutaiba A., Juyal, Ashima, and Garousi, Nazila
- Subjects
DRINKING (Physiology) ,RISK assessment ,STATISTICAL models ,MATERNAL exposure ,PREMATURE infants ,META-analysis ,SYSTEMATIC reviews ,MEDLINE ,ODDS ratio ,WATER ,ARSENIC ,ONLINE information services ,CONFIDENCE intervals ,DATA analysis software ,REGRESSION analysis ,PREGNANCY - Abstract
The relation of exposure to arsenic in drinking water during pregnancy to the risk of preterm birth (PTB) was contradictory. This meta-analysis aimed to examine the association between drinking water arsenic and PTB. A systematic search in PubMed and Scopus was performed to achieve all relevant studies. Odds ratios (OR) and 95% confidence intervals (CI) were used to pool data using the random-effect models. Overall, 11 studies with a total sample size of 3,404,189 participants were included in the meta-analysis. Arsenic exposure through drinking water during pregnancy was related to an increased risk of PTB (OR = 1.06; 95%CI = 1.01–1.10 for highest versus lowest category of arsenic), with significant heterogeneity across the studies (I
2 = 84.8%, P = 0.001). This finding was supported by cohort studies (OR = 1.05; 95%CI = 1.01–1.10). This meta-analysis proposes that higher arsenic exposure in drinking water may be a risk factor for PTB. [ABSTRACT FROM AUTHOR]- Published
- 2024
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