1. Targeted Lipidomics and Inflammation Response to Six Weeks of Sprint Interval Training in Male Adolescents
- Author
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Aozhe Wang, Haifeng Zhang, Jianming Liu, Zhiyi Yan, Yaqi Sun, Wantang Su, Ji-Guo Yu, Jing Mi, and Li Zhao
- Subjects
Idrottsvetenskap ,inflammation ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,lipidomics ,male adolescent ,sprint interval training ,Sport and Fitness Sciences - Abstract
Lipids play an important role in coordinating and regulating metabolic and inflammatory processes. Sprint interval training (SIT) is widely used to improve sports performance and health outcomes, but the current understanding of SIT-induced lipid metabolism and the corresponding systemic inflammatory status modification remains controversial and limited, especially in male adolescents. To answer these questions, twelve untrained male adolescents were recruited and underwent 6 weeks of SIT. The pre- and post-training testing included analyses of peak oxygen consumption (VO2peak), biometric data (weight and body composition), serum biochemical parameters (fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerol, testosterone, and cortisol), inflammatory markers, and targeted lipidomics. After the 6-week SIT, the serum C-reactive protein (CRP), interleukin (IL)-1β, IL-2, IL-4, IL-10, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-β significantly decreased (p < 0.05), whereas IL-6 and IL-10/TNF-α significantly increased (p < 0.05). In addition, the targeted lipidomics revealed changes in 296 lipids, of which 33 changed significantly (p < 0.05, fold change > 1.2 or
- Published
- 2023
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