4 results on '"Carsin, Anne‐Elie"'
Search Results
2. A three-generation study on the association of tobacco smoking with asthma
- Author
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Accordini, Simone, Calciano, Lucia, Johannessen, Ane, Portas, Laura, Benediktsdóttir, Bryndis, Bertelsen, Randi Jacobsen, Bråbäck, Lennart, Carsin, Anne-Elie, Dharmage, Shyamali C, Dratva, Julia, Forsberg, Bertil, Gomez Real, Francisco, Heinrich, Joachim, Holloway, John W, Holm, Mathias, Janson, Christer, Jögi, Rain, Leynaert, Bénédicte, Malinovschi, Andrei, Marcon, Alessandro, Martínez-Moratalla Rovira, Jesús, Raherison, Chantal, Sánchez-Ramos, José Luis, Schlünssen, Vivi, Bono, Roberto, Corsico, Angelo G, Demoly, Pascal, Dorado Arenas, Sandra, Nowak, Dennis, Pin, Isabelle, Weyler, Joost, Jarvis, Deborah, Svanes, Cecilie, Accordini, Simone, Calciano, Lucia, Johannessen, Ane, Portas, Laura, Benediktsdóttir, Bryndis, Bertelsen, Randi Jacobsen, Bråbäck, Lennart, Carsin, Anne-Elie, Dharmage, Shyamali C, Dratva, Julia, Forsberg, Bertil, Gomez Real, Francisco, Heinrich, Joachim, Holloway, John W, Holm, Mathias, Janson, Christer, Jögi, Rain, Leynaert, Bénédicte, Malinovschi, Andrei, Marcon, Alessandro, Martínez-Moratalla Rovira, Jesús, Raherison, Chantal, Sánchez-Ramos, José Luis, Schlünssen, Vivi, Bono, Roberto, Corsico, Angelo G, Demoly, Pascal, Dorado Arenas, Sandra, Nowak, Dennis, Pin, Isabelle, Weyler, Joost, Jarvis, Deborah, and Svanes, Cecilie
- Abstract
Background: Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results: Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). Conclusions: Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
- Published
- 2019
3. A three-generation study on the association of tobacco smoking with asthma.
- Author
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Accordini, Simone, Calciano, Lucia, Johannessen, Ane, Portas, Laura, Benediktsdóttir, Bryndis, Bertelsen, Randi Jacobsen, Bråbäck, Lennart, Carsin, Anne-Elie, Dharmage, Shyamali C, Dratva, Julia, Forsberg, Bertil, Gomez Real, Francisco, Heinrich, Joachim, Holloway, John W, Holm, Mathias, Janson, Christer, Jögi, Rain, Leynaert, Bénédicte, Malinovschi, Andrei, and Marcon, Alessandro
- Subjects
ASTHMA in pregnancy ,PHYSIOLOGICAL effects of tobacco ,CONFIDENCE intervals ,PLAUSIBILITY (Logic) ,ODDS ratio ,ASTHMA ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,PARENTS ,REGRESSION analysis ,RESEARCH ,RESEARCH funding ,STATISTICS ,SURVEYS ,EVALUATION research ,PRENATAL exposure delayed effects - Abstract
Background: Mothers' smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers' smoking may have a similar effect, and biological plausibility that fathers' smoking during adolescence may influence offspring's health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma.Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents' (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines.Results: Fathers' smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01-2.01] and mothers' smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers' smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55).Conclusions: Fathers' smoking during early adolescence and grandmothers' and mothers' smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.Funding: European Union (Horizon 2020, GA-633212). [ABSTRACT FROM AUTHOR]- Published
- 2018
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4. Father's environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe study.
- Author
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Svanes, Cecilie, Koplin, Jennifer, Skulstad, Svein Magne, Johannessen, Ane, Bertelsen, Randi Jakobsen, Benediktsdottir, Byndis, Bråbäck, Lennart, Carsin, Anne Elie, Dharmage, Shyamali, Dratva, Julia, Forsberg, Bertil, Gislason, Thorarinn, Heinrich, Joachim, Holm, Mathias, Janson, Christer, Jarvis, Deborah, Jögi, Rain, Krauss-Etschmann, Susanne, Lindberg, Eva, and Macsali, Ferenc
- Subjects
ASTHMA in children ,CHILDREN'S health ,PHYSIOLOGICAL effects of tobacco ,CONFIDENCE intervals ,ENVIRONMENTAL exposure ,ASTHMA risk factors ,ASTHMA ,COMPARATIVE studies ,FATHERS ,GENES ,INTERNATIONAL relations ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,METALLURGY ,RESEARCH ,SMOKING ,LOGISTIC regression analysis ,OCCUPATIONAL hazards ,EVALUATION research - Abstract
Background: Whereas it is generally accepted that maternal environment plays a key role in child health, emerging evidence suggests that paternal environment before conception also impacts child health. We aimed to investigate the association between children's asthma risk and parental smoking and welding exposures prior to conception.Methods: In a longitudinal, multi-country study, parents of 24 168 offspring aged 2-51 years provided information on their life-course smoking habits, occupational exposure to welding and metal fumes, and offspring's asthma before/after age 10 years and hay fever. Logistic regressions investigated the relevant associations controlled for age, study centre, parental characteristics (age, asthma, education) and clustering by family.Results: Non-allergic early-onset asthma (asthma without hay fever, present in 5.8%) was more common in the offspring with fathers who smoked before conception {odds ratio [OR] = 1.68 [95% confidence interval (CI) = 1.18-2.41]}, whereas mothers' smoking before conception did not predict offspring asthma. The risk was highest if father started smoking before age 15 years [3.24 (1.67-6.27)], even if he stopped more than 5 years before conception [2.68 (1.17-6.13)]. Fathers' pre-conception welding was independently associated with non-allergic asthma in his offspring [1.80 (1.29-2.50)]. There was no effect if the father started welding or smoking after birth. The associations were consistent across countries.Conclusions: Environmental exposures in young men appear to influence the respiratory health of their offspring born many years later. Influences during susceptible stages of spermatocyte development might be important and needs further investigation in humans. We hypothesize that protecting young men from harmful exposures may lead to improved respiratory health in future generations. [ABSTRACT FROM AUTHOR]- Published
- 2017
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