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The objective was to investigate the safety and efficacy of the nutrition protocol in enhanced recovery after surgery (ERAS) of hypopharyngeal cancer. Protocol focus was patient consumption of nutritional supplements perioperatively. In this retrospective study, a total of 78 patients with hypopharyngeal cancer were divided into the ERAS group (n = 39) and the control group (n = 39). The data were collected from two groups of three time points: 1 day before surgery, 1 day after surgery, and 7 days after surgery. The difference between two groups of the nutritional and immune status, postoperative exhaust time, hospitalization expense and hospitalization time were compared. The nutritional and immune status in the ERAS group were better than that in the control group at 7 days after surgery (P <.05); The hospitalization expense and hospitalization time in the ERAS group were lower comparing with the control group (P <.05). Our nutrition protocol is effective and safe in ERAS of patients with hypopharyngeal cancer. It's significant to implement ERAS of hypopharyngeal cancer patients with nutritional protocol during peroperative period, which will improve immune system, maintain health metabolic functions, and reduce the hospitalization time as well as the hospitalization expense. [ABSTRACT FROM AUTHOR]