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This paper investigated the installation effects of a driven prestressed high-strength concrete (PHC) nodular pile in deep soft clay through full-scale tests, and the behavior of a driven PHC nodular pile is analyzed based on the field test results. The test results demonstrated that the driven PHC nodular pile installation process induced significant disturbance in the surrounding soil. The excess pore water pressures (Δu) that were induced by the installation of a driven PHC nodular pile were larger than the Δu that were induced by the installation of a driven PHC pipe pile. The driven PHC nodular pile installation caused significant Δu in the soil down to 2 m below the pile base, and the Δu became much smaller in the soil at 4 m below the pile base. The Δu dissipated slowly in the soft clay layers, and the Δu in the surficial soil layers dissipated faster than that in the deep soil layers. The nodules along the PHC nodular pile shaft could increase the pile shaft capacity. The measured shaft resistances of 350(400)-mm PHC nodular piles were 1.17–1.18 times the calculated shaft resistances of 350-mm PHC pipe piles in soft clay layers. [ABSTRACT FROM AUTHOR]