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• The desirable operating conditions to achieve high operational efficiency are obtained. • The performance of the IEC under different operating conditions is investigated. • The mathematical model is validated against published data. • The optimal dimensions that give good efficiency in climates with moderate humidity are highlighted. [Display omitted] This paper presents a study investigating and analyzing the effect of heat and mass exchanger (HMX) dimensions and the flow parameters on the indirect evaporative cooler (IEC) system's performance. For this purpose, a mathematical model based on heat and mass transfer concepts was developed, and the model was verified using experimental and simulation results from published papers. Simulations were performed based on different operating and structural conditions affecting the outlet air temperature, cooling capacity, coefficient of performance, and wet-bulb efficiency. Results showed that the optimal dimensions that give good efficiency in climates with moderate humidity, the length of the duct should be between 0.6 to 1.0 m , the width of the channel between 0.3 to 0.5 m , and the channel gap between 0.004 to 0.008 m. It has also been observed that the increasing working air velocity has a positive effect on cooling performance, and its velocity should not be less than 1 m / s. As for increasing the product air velocity, it reduces the heat exchange period, which is undesirable, so it should not exceed 1 m / s. The prescribed flow rate ratio between product and working air should be 0.3 to 0.5. This analysis provides desirable operating conditions to achieve high operational efficiency as well as optimal dimensions for designing such a cooler. [ABSTRACT FROM AUTHOR]