1. Interdigitating dendritic cell sarcoma presenting simultaneously with acute myelomonocytic leukemia: report of a rare case and literature review.
- Author
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Jiang YZ, Dong NZ, Wu DP, and Xue SL
- Subjects
- Biopsy, Dendritic Cell Sarcoma, Interdigitating diagnosis, Dendritic Cell Sarcoma, Interdigitating drug therapy, Fatal Outcome, Female, Humans, Immunohistochemistry, Interleukin-3 Receptor alpha Subunit metabolism, Leukemia, Myelomonocytic, Acute diagnosis, Leukemia, Myelomonocytic, Acute drug therapy, Leukosialin metabolism, Lymph Nodes pathology, Middle Aged, Dendritic Cell Sarcoma, Interdigitating complications, Leukemia, Myelomonocytic, Acute complications
- Abstract
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare tumor derived from interdigitating dendritic cells. We report the first case of a 64-year-old Chinese woman who was diagnosed with simultaneous IDCS and acute myelomonocytic leukemia (AML-M4). The patient had undergone chemotherapy for breast cancer 6 years previously. Based on the laboratory results, both the IDCS and the AML-M4 in this patient were determined to be of myelogenous origination. Furthermore, a review of 62 IDCS cases (Medline database, key word: IDCS) reported to date revealed that as many as 17 % of the patients had malignant disease and received radiotherapy and/or chemotherapy prior to developing IDCS, and that this group of patients showed worse prognosis compared with counterparts. The patient in the present report showed poor response to four cycles of sequential chemotherapy, and died 6 months after the initial diagnosis.
- Published
- 2013
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