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Background: Millions of workers are exposed to polycyclic aromatic hydrocarbons (PAHs), a well-known family of carcinogens, but occupational exposure data about PAH mixture compositions are scarce.Objectives: To provide a detailed picture of airborne PAH exposures encountered in the French industrial landscape over the previous 20 years and to identify determinants driving exposures.Methods: Results from 1643 airborne samples of 16 gaseous and particulate PAHs implemented into the Exporisq HAP database from 1995 to 2014 were used to describe exposure levels and aerosol chemical composition in many industries and activities. Compliance of benzo[a]pyrene (BaP) levels with several existing occupational exposure limits for long-term exposure was assessed.Results: BaP levels were lower than those reported in the literature, but the level and composition of PAH mixtures were highly variable between and within industries. Numerous exposure determinants (e.g., product composition, type and temperature of process, ventilation and confinement) were assumed to explain these differences. The highest levels were found in industries using products derived from coal (aluminum, silicon, and coke production, manufacturing of carbon products and foundries), with mean BaP levels up to 23 times higher than the French recommended value of 150 ng/m3. Forty-seven percent of the occupational activities exceeded this value. Conversely, exposures resulting from petroleum-derived products were relatively low.Conclusions: As health effects depend on PAH levels but also on the composition of the mixture, exposure assessments must characterize the entire mixtures and record specific determinants to define homogeneous exposure groups and to accurately assess health risks. [ABSTRACT FROM AUTHOR]

Background: Knowledge of hazards and exposure data about chemical pollutants are essential for epidemiological studies for assessing health risks and preventing the development of diseases. Access to this type of information is clearly needed and although numerous databases (DBs) have been compiled, they are often extremely difficult to find and navigate.Objectives: This paper presents the creation of an online inventory of toxicological and exposure DBs to support human health risk assessment resulting from the chemical exposome.Methods: A free searchable online inventory, called TEDI (Toxicological and Exposure Database Inventory), was set up to collect meta-data on toxicological and exposure DBs resulting from a review of the literature conducted on PubMed. Only chemical agents, including drugs, natural and manufactured/synthetic chemicals and air pollutants, were considered. Regarding exposure DBs, only human exposure to chemicals were included. Because of time and resource constraints, only an inventory was performed, and no effort was made to rate, assess or rank DBs on quality criteria.Results: A total of 715 DBs were identified, catalogued, described and made available on TEDI. The number of chemicals ranged from one single chemical to 90 million for toxicological DBs and from 1 to 103,817 chemicals for exposure DBs. Some DBs were restricted to specific chemicals, with for instance 71 exposure DBs reporting polycyclic aromatic hydrocarbon measurements. Toxicological DBs (n = 362) provided a broad range of different information such as toxicity data (57%), physicochemical properties (38%), experimental study results (28%) or prediction data (16%). A total of 382 exposure DBs were found, including exposure measurements DBs (71%), web application/tool (21%), exposure and risk assessment models (19%) and epidemiological DBs (13%).Discussion: TEDI is of value to the broader community and could support human health risk assessment to chemicals in various contexts. This inventory remains open for further additions, to enlarge its coverage, increase the meta-data collected and include newly developed DBs. [ABSTRACT FROM AUTHOR]