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• Central lines are essential vascular access devices that can be associated with bloodstream infections. • This position paper overviews the techniques relevent to the insertion of these devices and procedures to maintain the catheter. • The paper also underscores the differences in management problems between high and middle to low income countries and between adults and children. • This paper also overviews the diagnosis and choice of antimicrobials in the treatment of central line-associated bloodstream infections. A panel of experts was convened by the International Society for Infectious Diseases (ISID) to overview recommendations on managing and preventing vascular catheter infections, specifically for the prevention and management of central line-associated bloodstream infections. These recommendations are intended to provide insight for healthcare professionals regarding the prevention of infection in the placement and maintenance of the catheter and diagnosis as well as treatment of catheter infection. Aspects of this area in pediatrics and in limited-resource situations and a discussion regarding the selection of empiric or targeted antimicrobial therapy are particular strengths of this position paper. [ABSTRACT FROM AUTHOR]