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CORONA virus disease -19 (COVID-19) is a disease caused by SARS-CoV-2. The outbreak started from Wuhan, China in Dec'2019 and became a pandemic. Human to human transmission occurs through droplet, fomites, aerosol and contaminated surfaces.This study shows that use of portable air purifier in patient's room can actually reduce the viral load in the room air that might minimize the risk of acquiring COVID through air-borne transmission by heath care professional taking care of the COVID patients. The study was carried out in room/cabins of special ward in LN Hospital, New Delhi where recently detected (within 48 Hr of RT-PCR +Ve results) COVID-19 patient with cough were admitted for treatment.The COVID-19 patients were asked to cough on the petri dish fixed with a polyvinylidene fluoride (PVDF) membrane filter (80 mm in diameter and 3 um pore size) keeping it within 2 feet distances from his/her nose for 15 mins. Then the membrane was then removed and added to falcon tube (15ML) containing 3 ML of viral transport medium (VTM). The tube were sent to PCR lab in an ice box. Air sampler was run for 1Hr keeping it at 3 Meter distance from recently diagnosed COVID-19 patient. RT-PCR done from particulate matters collected in VTM from the air sampler.Air sampler was run similarly and RT-PCR was done from PM collected in the filter of air sampler. The primary air suction was done at two different air flow 16.7 and 27 litre per minute (LPM), after which both RDRP and E gene were positive, after the use of purifier both the genes were still positive but with increased Ct values. With continous use of the air purifier the viral load of COVID-19 present in the air of ICU with paitents is primarily reduced but not completely eliminated. [ABSTRACT FROM AUTHOR]