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Start Over Author "Riess, R." Journal international journal of legal medicine
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2. Immunohistochemical investigations on the course of astroglial GFAP expression following human brain injury

Author

R. Hausmann, A. Fieguth, P. Betz, and Riess R

Subjects
Adult, Aged, 80 and over, Pathology, medicine.medical_specialty, Adolescent, TOPOGRAPHIC REGIONS, Human brain, Biology, Forensic Medicine, Middle Aged, Immunohistochemistry, Pathology and Forensic Medicine, White matter, medicine.anatomical_structure, Morphometric analysis, Age estimation, Cortex (anatomy), Astrocytes, Brain Injuries, Glial Fibrillary Acidic Protein, medicine, Humans, Child, Aged
Abstract

The course of GFAP expression by astrocytes has been immunohistochemically investigated during the first 30 weeks after human brain injury. In order to provide reliable data for a forensic wound age estimation, a quantitative morphometric analysis was performed considering the different topographic regions of the cortex as well as of the white matter. Compared to the GFAP immunoreactivity in unaltered control tissue, significantly increased numbers of GFAP positive astroglial cells could be detected adjacent to the cortical contusion from 1 day up to 4 weeks after brain injury.

Published
2000

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