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Hybrid nanofluids are capable of being used as a carrier for delivering drugs to targeted areas in the body. For this purpose, the Casson hybrid nanofluids (HNFs) flow is suggested between the gap of two tubes. The study involves analyzing blood-based hybrid nanofluids (HNFs) that consist of silver (Ag) and titanium dioxide (TiO2) nanoparticles for applications of drug delivery. Titanium oxide nanoparticles, or TiO2 NPs, have strong photoactivity, low toxicity, and excellent biocompatibility, making them promising candidates for cancer treatment. The attractiveness of silver nanoparticles (AgNPs) for cancer therapy is due to their unique properties. Graphic representations are provided based on the simulations of non-dimensional velocity, temperature, and skin friction under physical parameter variations, for the applications of drug delivery are investigated and discussed. The control volume finite element method (CVFEM), is used to solve the problem. The new strategy of artificial neural networks (ANN) is also used to solve the transform equations. Nanoparticles increase drug stability and extend shelf life by protecting them from degradation or inactivation. [ABSTRACT FROM AUTHOR]