1. COVID-19—The Shift of Homeostasis into Oncopathology or Chronic Fibrosis in Terms of Female Reproductive System Involvement.
- Author
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Petersen, Elena, Chudakova, Daria, Erdyneeva, Daiana, Zorigt, Dulamsuren, Shabalina, Evgeniya, Gudkov, Denis, Karalkin, Pavel, Reshetov, Igor, and Mynbaev, Ospan A.
- Subjects
GENITALIA ,COVID-19 ,COVID-19 pandemic ,FIBROSIS ,HOMEOSTASIS ,PUBLIC health - Abstract
The COVID-19 pandemic caused by the SARS-CoV-2 coronavirus remains a global public health concern due to the systemic nature of the infection and its long-term consequences, many of which remain to be elucidated. SARS-CoV-2 targets endothelial cells and blood vessels, altering the tissue microenvironment, its secretion, immune-cell subpopulations, the extracellular matrix, and the molecular composition and mechanical properties. The female reproductive system has high regenerative potential, but can accumulate damage, including due to SARS-CoV-2. COVID-19 is profibrotic and can change the tissue microenvironment toward an oncogenic niche. This makes COVID-19 and its consequences one of the potential regulators of a homeostasis shift toward oncopathology and fibrosis in the tissues of the female reproductive system. We are looking at SARS-CoV-2-induced changes at all levels in the female reproductive system. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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