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Your search keyword '"Finotti, Alessia"' showing total 8 results
Start Over Author "Finotti, Alessia" Search Limiters Peer Reviewed Journal international journal of molecular sciences
8 results on '"Finotti, Alessia"'

2. Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus

Author

Zurlo, Matteo, primary, Zuccato, Cristina, additional, Cosenza, Lucia Carmela, additional, Gasparello, Jessica, additional, Gamberini, Maria Rita, additional, Stievano, Alice, additional, Fortini, Monica, additional, Prosdocimi, Marco, additional, Finotti, Alessia, additional, and Gambari, Roberto, additional

Published
2023
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3. The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers

Author

Zuccato, Cristina, primary, Cosenza, Lucia Carmela, additional, Zurlo, Matteo, additional, Breveglieri, Giulia, additional, Bianchi, Nicoletta, additional, Lampronti, Ilaria, additional, Gasparello, Jessica, additional, Scapoli, Chiara, additional, Borgatti, Monica, additional, Finotti, Alessia, additional, and Gambari, Roberto, additional

Published
2023
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4. Combined Treatment of Bronchial Epithelial Calu-3 Cells with Peptide Nucleic Acids Targeting miR-145-5p and miR-101-3p: Synergistic Enhancement of the Expression of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene

Author

Papi, Chiara, primary, Gasparello, Jessica, additional, Zurlo, Matteo, additional, Manicardi, Alex, additional, Corradini, Roberto, additional, Cabrini, Giulio, additional, Gambari, Roberto, additional, and Finotti, Alessia, additional

Published
2022
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7. Synergistic Effects of A Combined Treatment of Glioblastoma U251 Cells with An Anti-miR-10b-5p Molecule and An AntiCancer Agent Based on 1-(3′,4′,5′-Trimethoxyphenyl)-2-Aryl-1 H -Imidazole Scaffold.

Author

Zurlo, Matteo, Romagnoli, Romeo, Oliva, Paola, Gasparello, Jessica, Finotti, Alessia, and Gambari, Roberto

Subjects
CENTRAL nervous system cancer, TUBULINS, GLIOBLASTOMA multiforme, ANTINEOPLASTIC agents, MOLECULES
Abstract

(1) Background: In the development of new and more effective anticancer approaches, combined treatments appear of great interest. Combination therapy could be of importance in the management of glioblastoma (GBM), a lethal malignancy that accounts for 42% of cancer of the central nervous system, with a median survival of 15 months. This study aimed to verify the activity on a glioblastoma cancer cell line of one of the most active compounds of a novel series of tubulin polymerization inhibitors based on the 1-(3′,4′,5′-trimethoxyphenyl)-2-aryl-1H-imidazole scaffold, used in combination with a miRNA inhibitor molecule targeting the oncomiRNA miR-10b-5p. This microRNA was selected in consideration of the role of miR-10b-5p on the onset and progression of glioblastoma. (2) Methods: Apoptosis was analyzed by Annexin-V and Caspase 3/7 assays, efficacy of the anti-miR-10b-5p was assessed by determining the miR-10b-5p content by RT-qPCR. (3) Results: The results obtained show that a "combination therapy" performed by combining the use of an anti-miR-10b-5p and a 1-(3′,4′,5′-trimethoxyphenyl)-2-aryl-1H-imidazole derivative is an encouraging strategy to boost the efficacy of anticancer therapies and at the same time to reduce side effects. [ABSTRACT FROM AUTHOR]

Published
2022
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