1. BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine.
- Author
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Cao Z, Jia Y, and Zhu B
- Subjects
- Animals, Diagnosis, Gene Expression Regulation, Heart Failure etiology, Heart Function Tests, Humans, Natriuretic Peptide, Brain genetics, Peptide Fragments genetics, Prognosis, Proteolysis, Severity of Illness Index, Signal Transduction, Translational Research, Biomedical, Biomarkers, Forensic Medicine, Heart Failure diagnosis, Heart Failure metabolism, Natriuretic Peptide, Brain metabolism, Peptide Fragments metabolism
- Abstract
Currently, brain natriuretic peptide (BNP) and N -terminal proBNP (NT-proBNP) are widely used as diagnostic biomarkers for heart failure (HF) and cardiac dysfunction in clinical medicine. They are also used as postmortem biomarkers reflecting cardiac function of the deceased before death in forensic medicine. Several previous studies have reviewed BNP and NT-proBNP in clinical medicine, however, few articles have reviewed their application in forensic medicine. The present article reviews the biological features, the research and application status, and the future research prospects of BNP and NT-proBNP in both clinical medicine and forensic medicine, thereby providing valuable assistance for clinicians and forensic pathologists.
- Published
- 2019
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