1. The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant.
- Author
-
Arora, Prerna, Zhang, Lu, Rocha, Cheila, Graichen, Luise, Nehlmeier, Inga, Kempf, Amy, Cossmann, Anne, Ramos, Gema Morillas, Baier, Eva, Tampe, Björn, Moerer, Onnen, Dickel, Steffen, Winkler, Martin S., Behrens, Georg M. N., Pöhlmann, Stefan, and Hoffmann, Markus
- Subjects
SARS-CoV-2 Omicron variant ,SARS-CoV-2 Delta variant ,SARS-CoV-2 ,RECOMBINANT viruses ,BREAKTHROUGH infections ,VIRAL tropism - Abstract
Recently, a recombinant SARS-CoV-2 lineage, XD, emerged that harbors a spike gene that is largely derived from the Omicron variant BA.1 in the genetic background of the Delta variant. This finding raised concerns that the recombinant virus might exhibit altered biological properties as compared to the parental viruses and might pose an elevated threat to human health. Here, using pseudotyped particles, we show that ACE2 binding and cell tropism of XD mimics that of BA.1. Further, XD and BA.1 displayed comparable sensitivity to neutralization by antibodies induced upon vaccination with BNT162b2/Comirnaty (BNT) or BNT vaccination followed by breakthrough infection. Our findings reveal important biological commonalities between XD and Omicron BA.1 host cell entry and its inhibition by antibodies. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF