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Start Over Author "Atanasov, Atanas" Journal international journal of molecular sciences
16 results on '"Atanasov, Atanas"'

3. Effect of Dried Apple Pomace (DAP) as a Feed Additive on Antioxidant System in the Rumen Fluid

Author

Bartel, Iga, primary, Koszarska, Magdalena, additional, Wysocki, Kamil, additional, Kozłowska, Martyna, additional, Szumacher-Strabel, Małgorzata, additional, Cieślak, Adam, additional, Wyrwał, Beata, additional, Szejner, Aleksandra, additional, Strzałkowska, Nina, additional, Horbańczuk, Jarosław Olav, additional, Atanasov, Atanas G., additional, and Jóźwik, Artur, additional

Published
2022
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5. Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis

Author

Haque, Effi, primary, Karim, M. Rezaul, additional, Salam Teeli, Aamir, additional, Śmiech, Magdalena, additional, Leszczynski, Paweł, additional, Winiarczyk, Dawid, additional, Parvanov, Emil D., additional, Atanasov, Atanas G., additional, and Taniguchi, Hiroaki, additional

Published
2020
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7. (+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line

Author

Souto, Eliana B., primary, Zielinska, Aleksandra, additional, Souto, Selma B., additional, Durazzo, Alessandra, additional, Lucarini, Massimo, additional, Santini, Antonello, additional, Silva, Amélia M., additional, Atanasov, Atanas G., additional, Marques, Conrado, additional, Andrade, Luciana N., additional, and Severino, Patricia, additional

Published
2020
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11. Inhibitory Effect of CAPE and Kaempferol in Colon Cancer Cell Lines—Possible Implications in New Therapeutic Strategies

Author

Budisan, Liviuta, primary, Gulei, Diana, additional, Jurj, Ancuta, additional, Braicu, Cornelia, additional, Zanoaga, Oana, additional, Cojocneanu, Roxana, additional, Pop, Laura, additional, Raduly, Lajos, additional, Barbat, Alexandru, additional, Moldovan, Alin, additional, Moldovan, Cristian, additional, Tigu, Adrian, additional, Ionescu, Calin, additional, Atanasov, Atanas, additional, Irimie, Alexandru, additional, and Berindan-Neagoe, Ioana, additional

Published
2019
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13. Phytochemicals for the Prevention and Treatment of Gastric Cancer: Effects and Mechanisms.

Author

Qian-Qian Mao, Xiao-Yu Xu, Ao Shang, Ren-You Gan, Ding-Tao Wu, Atanasov, Atanas G., and Hua-Bin Li

Subjects
STOMACH cancer, CANCER cell proliferation, PHYTOCHEMICALS, CANCER treatment, GUT microbiome, HELICOBACTER pylori
Abstract

Gastric cancer is the fifth most common cancer, and the third most prevalent cause of cancer-related deaths in the world. Voluminous evidence has demonstrated that phytochemicals play a critical role in the prevention and management of gastric cancer. Most epidemiological investigations indicate that the increased intake of phytochemicals could reduce the risk of gastric cancer. Experimental studies have elucidated the mechanisms of action, including inhibiting cancer cell proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis as well as cancer cell metastasis. These mechanisms have also been related to the inhibition of Helicobacter pylori and the modulation of gut microbiota. In addition, the intake of phytochemicals could enhance the efficacy of anticancer chemotherapeutics. Moreover, clinical studies have illustrated that phytochemicals have the potential for the prevention and the management of gastric cancer in humans. To provide an updated understanding of relationships between phytochemicals and gastric cancer, this review summarizes the effects of phytochemicals on gastric cancer, highlighting the underlying mechanisms. This review could be helpful for guiding the public in preventing gastric cancer through phytochemicals, as well as in developing functional food and drugs for the prevention and treatment of gastric cancer. [ABSTRACT FROM AUTHOR]

Published
2020
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14. Current Insights into Oral Cancer Epigenetics

Author

Irimie, Alexandra, primary, Ciocan, Cristina, additional, Gulei, Diana, additional, Mehterov, Nikolay, additional, Atanasov, Atanas, additional, Dudea, Diana, additional, and Berindan-Neagoe, Ioana, additional

Published
2018
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15. An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Author

Atanas G. Atanasov, Amirhossein Nazhand, Massimo Lucarini, Eliana B. Souto, Ettore Novellino, Raffaele Capasso, Antonello Santini, Alessandra Durazzo, Durazzo, Alessandra, Nazhand, Amhirossein, Lucarini, Massimo, Atanasov, Atanas G., Souto, Eliana B., Novellino, Ettore, Capasso, Raffaele, Santini, Antonello, and Universidade do Minho

Subjects
0301 basic medicine, Computer science, Synbiotics, 02 engineering and technology, Review, Catalysis, Inorganic Chemistry, lcsh:Chemistry, nanotechnologie, 03 medical and health sciences, Nutraceutical, Animals, Humans, Nanotechnology, Physical and Theoretical Chemistry, synbiotics, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, nutraceuticals, Science & Technology, Organic Chemistry, General Medicine, Area of interest, nanonutraceutical, 021001 nanoscience & nanotechnology, 3. Good health, Computer Science Applications, nanonutraceuticals, 030104 developmental biology, Intestinal Absorption, probiotics, lcsh:Biology (General), lcsh:QD1-999, Research strategies, prebiotic, Dietary Supplements, Nanoparticles, nutraceutical, Biochemical engineering, nanotechnologies, 0210 nano-technology, prebiotics, probiotic
Abstract

Over the last few years, the application of nanotechnology to nutraceuticals has been rapidly growing due to its ability to enhance the bioavailability of the loaded active ingredients, resulting in improved therapeutic/nutraceutical outcomes. The focus of this work is nanoprebiotics and nanoprobiotics, terms which stand for the loading of a set of compounds (e.g., prebiotics, probiotics, and synbiotics) in nanoparticles that work as absorption enhancers in the gastrointestinal tract. In this manuscript, the main features of prebiotics and probiotics are highlighted, together with the discussion of emerging applications of nanotechnologies in their formulation. Current research strategies are also discussed, in particular the promising use of nanofibers for the delivery of probiotics. Synbiotic-based nanoparticles represent an innovative trend within this area of interest. As only few experimental studies on nanoprebiotics and nanoprobiotics are available in the scientific literature, research on this prominent field is needed, covering effectiveness, bioavailability, and safety aspects., The authors acknowledge the support of the research project: Nutraceutica come supporto nutrizionale nel paziente oncologico, CUP: B83D18000140007. E. B. Souto acknowledges the sponsorship of the projects M-ERA-NET-0004/2015-PAIRED and UIDB/04469/2020 (strategic fund), receiving support from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020., info:eu-repo/semantics/publishedVersion

Published
2020

16. (+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line

Author

Eliana B. Souto, Amélia M. Silva, Massimo Lucarini, Antonello Santini, Aleksandra Zielińska, Luciana Nalone Andrade, Conrado Marques, Alessandra Durazzo, Patrícia Severino, Atanas G. Atanasov, Selma B. Souto, Universidade do Minho, Souto, Eliana B., Zielinska, Aleksandra, Souto, Selma B., Durazzo, Alessandra, Lucarini, Massimo, Santini, Antonello, Silva, Amélia M., Atanasov, Atanas G., Marques, Conrado, Andrade, Luciana N., and Severino, Patricia

Subjects
Keratinocytes, Antioxidant, medicine.medical_treatment, 02 engineering and technology, Imwitor 900K-SLN, 030226 pharmacology & pharmacy, Antioxidants, lcsh:Chemistry, Lipid peroxidation, chemistry.chemical_compound, 0302 clinical medicine, Glycerol monostearate, Cytotoxicity, lcsh:QH301-705.5, Spectroscopy, lipid peroxidation, General Medicine, 021001 nanoscience & nanotechnology, 3. Good health, Computer Science Applications, medicine.anatomical_structure, Monoglycerides, cytotoxicity, (+)-limonene 1,2-epoxide, 0210 nano-technology, Keratinocyte, Cyclohexane Monoterpenes, Poloxamer, Article, Catalysis, Cell Line, Inorganic Chemistry, 03 medical and health sciences, (+)-limonene 1, Solid lipid nanoparticle, medicine, Humans, Viability assay, Physical and Theoretical Chemistry, Molecular Biology, Science & Technology, Chromatography, Organic Chemistry, body regions, HaCaT, lcsh:Biology (General), lcsh:QD1-999, chemistry, HaCaT cell line, Delayed-Action Preparations, Nanoparticles, 2-epoxide, monoterpene
Abstract

In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer&reg, 188 in aqueous dispersion to modify the release profile of the loaded monoterpene derivative. We also evaluated the role of SLNs in lipid peroxidation and cytotoxicity in a spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (the HaCaT cell line). For the cell viability assay, the colorimetric 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used. Lim-SLNs with a loading capacity and encapsulation efficiency of 0.39% and 63%, respectively, were produced by high pressure homogenization. A mean particle size of 194 &plusmn, 3.4 nm and polydispersity index of 0.244 were recorded for the loaded Lim-SLNs, as compared to 203 &plusmn, 1.5 nm (PI 0.213) for the non-loaded (blank) SLNs. The loading of the monoterpene derivative into glycerol monostearate SLNs fitted into the zero-order kinetics, and ameliorated both lipid peroxidation and cytotoxicity in a keratinocyte cell line. A promising formulation for antioxidant and anti-tumoral activities is here proposed.

Published
2020

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