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Your search keyword '"Calogero, Aldo E."' showing total 13 results
Start Over Author "Calogero, Aldo E." Journal international journal of molecular sciences
13 results on '"Calogero, Aldo E."'

1. Insulin-like Growth Factor 1, Growth Hormone, and Anti-Müllerian Hormone Receptors Are Differentially Expressed during GnRH Neuron Development

Author

Paganoni, Alyssa J. J., primary, Cannarella, Rossella, additional, Oleari, Roberto, additional, Amoruso, Federica, additional, Antal, Renata, additional, Ruzza, Marco, additional, Olivieri, Chiara, additional, Condorelli, Rosita A., additional, La Vignera, Sandro, additional, Tolaj, Fationa, additional, Cariboni, Anna, additional, Calogero, Aldo E., additional, and Magni, Paolo, additional

Published
2023
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2. Genetic Analysis of Patients with Congenital Hypogonadotropic Hypogonadism: A Case Series

Author

Cannarella, Rossella, primary, Gusmano, Carmelo, additional, Condorelli, Rosita A., additional, Bernini, Andrea, additional, Kaftalli, Jurgen, additional, Maltese, Paolo Enrico, additional, Paolacci, Stefano, additional, Dautaj, Astrit, additional, Marceddu, Giuseppe, additional, Bertelli, Matteo, additional, La Vignera, Sandro, additional, and Calogero, Aldo E., additional

Published
2023
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4. Alpha-Lipoic Acid Reduces Cell Growth, Inhibits Autophagy, and Counteracts Prostate Cancer Cell Migration and Invasion: Evidence from In Vitro Studies.

Author

Bossio, Sabrina, Perri, Anna, Gallo, Raffaella, De Bartolo, Anna, Rago, Vittoria, La Russa, Daniele, Di Dio, Michele, La Vignera, Sandro, Calogero, Aldo E., Vitale, Giovanni, and Aversa, Antonio

Subjects
LIPOIC acid, CANCER cell migration, CELL growth, ANDROGEN receptors, PROSTATE cancer, CANCER cell growth
Abstract

Alpha-lipoic acid (ALA) is a natural antioxidant dithiol compound, exerting antiproliferative and antimetastatic effects in various cancer cell lines. In our study, we demonstrated that ALA reduces the cell growth of prostate cancer cells LNCaP and DU-145. Western blot results revealed that in both cancer cells, ALA, by upregulating pmTOR expression, reduced the protein content of two autophagy initiation markers, Beclin-1 and MAPLC3. Concomitantly, MTT assays showed that chloroquine (CQ) exposure, a well-known autophagy inhibitor, reduced cells' viability. This was more evident for treatment using the combination ALA + CQ, suggesting that ALA can reduce cells' viability by inhibiting autophagy. In addition, in DU-145 cells we observed that ALA affected the oxidative/redox balance system by deregulating the KEAP1/Nrf2/p62 signaling pathway. ALA decreased ROS production, SOD1 and GSTP1 protein expression, and significantly reduced the cytosolic and nuclear content of the transcription factor Nrf2, concomitantly downregulating p62, suggesting that ALA disrupted p62-Nrf2 feedback loop. Conversely, in LNCaP cells, ALA exposure upregulated both SOD1 and p62 protein expression, but did not affect the KEAP1/Nrf2/p62 signaling pathway. In addition, wound-healing, Western blot, and immunofluorescence assays evidenced that ALA significantly reduced the motility of LNCaP and DU-145 cells and downregulated the protein expression of TGFβ1 and vimentin and the deposition of fibronectin. Finally, a soft agar assay revealed that ALA decreased the colony formation of both the prostate cancer cells by affecting the anchorage independent growth. Collectively, our in vitro evidence demonstrated that in prostate cancer cells, ALA reduces cell growth and counteracts both migration and invasion. Further studies are needed in order to achieve a better understanding of the underlined molecular mechanisms. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Effects of Follicle-Stimulating Hormone on Human Sperm Motility In Vitro

Author

Cannarella, Rossella, primary, Mancuso, Francesca, additional, Barone, Nunziata, additional, Arato, Iva, additional, Lilli, Cinzia, additional, Bellucci, Catia, additional, Musmeci, Marco, additional, Luca, Giovanni, additional, La Vignera, Sandro, additional, Condorelli, Rosita A., additional, and Calogero, Aldo E., additional

Published
2023
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6. Resistance to Thyroid Hormones: A Case-Series Study

Author

Cannarella, Rossella, primary, Musmeci, Marco, additional, Garofalo, Vincenzo, additional, Timpanaro, Tiziana A., additional, Leone, Guido, additional, Caruso, Manuela, additional, Maltese, Paolo E., additional, Condorelli, Rosita A., additional, La Vignera, Sandro, additional, and Calogero, Aldo E., additional

Published
2022
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7. Obesity and Male Reproduction: Do Sirtuins Play a Role?

Author

Barbagallo, Federica, primary, La Vignera, Sandro, additional, Cannarella, Rossella, additional, Mongioì, Laura M., additional, Garofalo, Vincenzo, additional, Leanza, Claudia, additional, Marino, Marta, additional, Calogero, Aldo E., additional, and Condorelli, Rosita A., additional

Published
2022
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10. Seminal Plasma Proteomic Biomarkers of Oxidative Stress

Author

Cannarella, Rossella, primary, Crafa, Andrea, additional, Barbagallo, Federica, additional, Mongioì, Laura M., additional, Condorelli, Rosita A., additional, Aversa, Antonio, additional, Calogero, Aldo E., additional, and La Vignera, Sandro, additional

Published
2020
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