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Your search keyword '"Careccia, A."' showing total 3 results
Start Over Author "Careccia, A." Journal international journal of molecular sciences
3 results on '"Careccia, A."'

1. Regulation of Satellite Cells Functions during Skeletal Muscle Regeneration: A Critical Step in Physiological and Pathological Conditions.

Author

Careccia, Giorgia, Mangiavini, Laura, and Cirillo, Federica

Subjects
*MUSCLE regeneration, *SATELLITE cells, *CELL physiology, *SKELETAL muscle, *CELLULAR control mechanisms, *MUSCULAR dystrophy
Abstract

Skeletal muscle regeneration is a complex process involving the generation of new myofibers after trauma, competitive physical activity, or disease. In this context, adult skeletal muscle stem cells, also known as satellite cells (SCs), play a crucial role in regulating muscle tissue homeostasis and activating regeneration. Alterations in their number or function have been associated with various pathological conditions. The main factors involved in the dysregulation of SCs' activity are inflammation, oxidative stress, and fibrosis. This review critically summarizes the current knowledge on the role of SCs in skeletal muscle regeneration. It examines the changes in the activity of SCs in three of the most common and severe muscle disorders: sarcopenia, muscular dystrophy, and cancer cachexia. Understanding the molecular mechanisms involved in their dysregulations is essential for improving current treatments, such as exercise, and developing personalized approaches to reactivate SCs. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Micro-Economics of Apoptosis in Cancer: ncRNAs Modulation of BCL-2 Family Members

Author

Silvia Careccia, Micol E. Fiori, Ruggero De Maria, and Lidia Villanova

Subjects
0301 basic medicine, Apoptotic program, RNA, Untranslated, therapy resistance, Review, Biology, Catalysis, Inorganic Chemistry, 03 medical and health sciences, long non-coding RNAs, BCL-2 family, Neoplasms, microRNA, medicine, cancer, Animals, Humans, Physical and Theoretical Chemistry, Treatment resistance, Molecular Biology, Spectroscopy, Organic Chemistry, Bcl-2 family, apoptosis, Cancer, General Medicine, medicine.disease, Computer Science Applications, Lymphoma, microRNAs, 030104 developmental biology, The Hallmarks of Cancer, Proto-Oncogene Proteins c-bcl-2, Apoptosis, Cancer research
Abstract

In the last few years, non-coding RNAs (ncRNAs) have been a hot topic in cancer research. Many ncRNAs were found to regulate the apoptotic process and to play a role in tumor cell resistance to treatment. The apoptotic program is on the frontline as self-defense from cancer onset, and evasion of apoptosis has been classified as one of the hallmarks of cancer responsible for therapy failure. The B-cell lymphoma 2 (BCL-2) family members are key players in the regulation of apoptosis and mediate the activation of the mitochondrial death machinery in response to radiation, chemotherapeutic agents and many targeted therapeutics. The balance between the pro-survival and the pro-apoptotic BCL-2 proteins is strictly controlled by ncRNAs. Here, we highlight the most common mechanisms exerted by microRNAs, long non-coding RNAs and circular RNAs on the main mediators of the intrinsic apoptotic cascade with particular focus on their significance in cancer biology.

Published
2018

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