1. Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer
- Author
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Guido Keijzers, Garik Mkrtchyan, Amanuel Teklu, Nils Gedsig Kirkelund Madsen, Michael A. Petr, Morten Scheibye-Knudsen, Brenna Osborne, and Daniela Bakula
- Subjects
0301 basic medicine ,Translesion DNA synthesis ,Cell cycle checkpoint ,DNA Repair ,Apoptosis ,Review ,EXO1 ,lcsh:Chemistry ,Neoplasms ,DNA Breaks, Double-Stranded ,Homologous Recombination ,translesion DNA synthesis ,lcsh:QH301-705.5 ,Spectroscopy ,Double strand break repair ,General Medicine ,Cell cycle ,Exonuclease 1 ,exonuclease 1 ,MMR ,Computer Science Applications ,Cell biology ,mismatch repair ,double strand break repair ,DNA mismatch repair ,DNA Replication ,Exonuclease ,DNA repair ,Biology ,Catalysis ,Mismatch repair ,Inorganic Chemistry ,03 medical and health sciences ,TLS ,Humans ,Physical and Theoretical Chemistry ,Molecular Biology ,Organic Chemistry ,DNA replication ,Cell Cycle Checkpoints ,nucleotide excision repair ,Strand displacements ,Nucleotide excision repair ,DNA Repair Enzymes ,Exodeoxyribonucleases ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,strand displacements ,NER ,biology.protein - Abstract
Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.
- Published
- 2018
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