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Your search keyword '"Hoffmann, Thomas"' showing total 12 results
Start Over Author "Hoffmann, Thomas" Journal international journal of molecular sciences
12 results on '"Hoffmann, Thomas"'

1. Influence of Bruton’s Tyrosine Kinase (BTK) on Epithelial–Mesenchymal Transition (EMT) Processes and Cancer Stem Cell (CSC) Enrichment in Head and Neck Squamous Cell Carcinoma (HNSCC)

Author

Leichtle, Franziska, primary, Betzler, Annika C., additional, Eizenberger, Carlotta, additional, Lesakova, Kristina, additional, Ezić, Jasmin, additional, Drees, Robert, additional, Greve, Jens, additional, Schuler, Patrick J., additional, Laban, Simon, additional, Hoffmann, Thomas K., additional, Cordes, Nils, additional, Lavitrano, Marialuisa, additional, Grassilli, Emanuela, additional, and Brunner, Cornelia, additional

Published
2023
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3. Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions

Author

von Witzleben, Adrian, primary, Müller-Richter, Urs, additional, Maurus, Katja, additional, Brändlein, Stephanie, additional, Theodoraki, Marie-Nicole, additional, Brunner, Cornelia, additional, Laban, Simon, additional, Lennerz, Jochen, additional, Möller, Peter, additional, Hoffmann, Thomas K., additional, Doescher, Johannes, additional, and Schuler, Patrick J., additional

Published
2022
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4. Immune Checkpoint Expression on Immune Cells of HNSCC Patients and Modulation by Chemo- and Immunotherapy

Author

Puntigam, Lisa K., Jeske, Sandra S., Götz, Marlies, Greiner, Jochen, Laban, Simon, Theodoraki, Marie-Nicole, Doescher, Johannes, Weissinger, Stephanie E., Brunner, Cornelia, Hoffmann, Thomas K., and Schuler, Patrick J.

Subjects
Adult, Male, Programmed Cell Death 1 Receptor, OX40 Ligand, chemical and pharmacologic phenomena, Alphapapillomavirus, immunomodulation, T-Lymphocytes, Regulatory, HNSCC, Article, Cohort Studies, lcsh:Chemistry, Lymphocytes, Tumor-Infiltrating, Humans, ddc:610, lcsh:QH301-705.5, Aged, Aged, 80 and over, Squamous Cell Carcinoma of Head and Neck, Middle Aged, immune checkpoints, Immune Checkpoint Proteins, Nivolumab, lcsh:Biology (General), lcsh:QD1-999, Head and Neck Neoplasms, Leukocytes, Mononuclear, Female, head and neck cancer, immunotherapy, checkpoint inhibitors
Abstract

Endogenous control mechanisms, including immune checkpoints and immunosuppressive cells, are exploited in the process of tumorigenesis to weaken the anti-tumor immune response. Cancer treatment by chemotherapy or immune checkpoint inhibition can lead to changes of checkpoint expression, which influences therapy success. Peripheral blood lymphocytes (PBL) and tumor-infiltrating lymphocytes (TIL) were isolated from head and neck squamous cell carcinoma (HNSCC) patients (n = 23) and compared to healthy donors (n = 23). Immune checkpoint expression (programmed cell death ligand 1 (PD-1), tumor necrosis factor receptor (TNFR)-related (GITR), CD137, tumor necrosis factor receptor superfamily member 4 (TNFRSF4) (OX40), t-cell immunoglobulin and mucin-domain containing-3 (TIM3), B- and T-lymphocyte attenuator (BTLA), lymphocyte-activation gene 3 (LAG3)) was determined on immune cells by flow cytometry. PD-L1 expression was detected on tumor tissue by immunohistochemistry. Immune cells were treated with immuno- and chemotherapeutics to investigate treatment-specific change in immune checkpoint expression, in vitro. Specific changes of immune checkpoint expression were identified on PBL and TIL of HNSCC patients compared to healthy donors. Various chemotherapeutics acted differently on the expression of immune checkpoints. Changes of checkpoint expression were significantly less pronounced on regulatory T cells compared to other lymphocyte populations. Nivolumab treatment significantly reduced the receptor PD-1 on all analyzed T cell populations, in vitro. The specific immune checkpoint expression patterns in HNSCC patients and the investigated effects of immunomodulatory agents may improve the development and efficacy of targeted immunotherapy.

Published
2020
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5. The Emerging Role of Exosomes in Diagnosis, Prognosis, and Therapy in Head and Neck Cancer

Author

Hofmann, Linda, Ludwig, Sonja, Vahl, Julius M., Brunner, Cornelia, Hoffmann, Thomas K., and Theodoraki, Marie-Nicole

Subjects
Clinical Decision-Making, Review, exosomes, Chemical Fractionation, Exosomes, HNSCC, Immunomodulation, lcsh:Chemistry, Extracellular Vesicles, liquid biomarker, Biomarkers, Tumor, Animals, Humans, tumor microenvironment, Squamous cell carcinoma of head and neck, ddc:610, %22">Exosom , lcsh:QH301-705.5, Liquid Biopsy, Disease Management, Plattenepithelcarcinom, Biomarker, Prognosis, Combined Modality Therapy, stomatognathic diseases, Treatment Outcome, Tumor microenvironment, Molecular Diagnostic Techniques, lcsh:Biology (General), lcsh:QD1-999, Head and Neck Neoplasms, Disease Progression, Disease Susceptibility, Exosom, DDC 610 / Medicine & health, Liquid biomarker, Biomarkers
Abstract

Exosomes, the smallest group of extracellular vesicles, carry proteins, miRNA, mRNA, DNA, and lipids, which they efficiently deliver to recipient cells, generating a communication network. Exosomes strongly contribute to the immune suppressive tumor microenvironment of head and neck squamous cell carcinomas (HNSCC). Isolation of exosomes from HNSCC cell culture or patient’s plasma allows for analyzing their molecular cargo and functional role in immune suppression and tumor progression. Immune affinity-based separation of different exosome subsets, such as tumor-derived or T cell-derived exosomes, from patient’s plasma simultaneously informs about tumor status and immune dysfunction. In this review, we discuss the recent understanding of how exosomes behave in the HNSCC tumor microenvironment and why they are promising liquid biomarkers for diagnosis, prognosis, and therapy in HNSCC., publishedVersion

Published
2020

7. CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation

Author

Dahlhaus, Meike, primary, Roos, Julian, additional, Engel, Daniel, additional, Tews, Daniel, additional, Halbgebauer, Daniel, additional, Funcke, Jan-Bernd, additional, Kiener, Sophie, additional, Schuler, Patrick J., additional, Döscher, Johannes, additional, Hoffmann, Thomas K., additional, Zinngrebe, Julia, additional, Rojewski, Markus, additional, Schrezenmeier, Hubert, additional, Debatin, Klaus-Michael, additional, Wabitsch, Martin, additional, and Fischer-Posovszky, Pamela, additional

Published
2020
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8. Peripheral Cytokine Levels Differ by HPV Status and Change Treatment-Dependently in Patients with Head and Neck Squamous Cell Carcinoma

Author

Mytilineos, Daphne, primary, Ezić, Jasmin, additional, von Witzleben, Adrian, additional, Mytilineos, Joannis, additional, Lotfi, Ramin, additional, Fürst, Daniel, additional, Tsamadou, Chrysanthi, additional, Theodoraki, Marie-Nicole, additional, Oster, Angelika, additional, Völkel, Gunnar, additional, Kestler, Hans A., additional, Brunner, Cornelia, additional, Schuler, Patrick J., additional, Doescher, Johannes, additional, Hoffmann, Thomas K., additional, and Laban, Simon, additional

Published
2020
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9. Characterization of the UDP-glycosyltransferase UGT72 Family in Poplar and Identification of Genes Involved in the Glycosylation of Monolignols

Author

Speeckaert, Nathanael, primary, Adamou, Nassirou Mahamadou, additional, Hassane, Hadjara Amadou, additional, Baldacci-Cresp, Fabien, additional, Mol, Adeline, additional, Goeminne, Geert, additional, Boerjan, Wout, additional, Duez, Pierre, additional, Hawkins, Simon, additional, Neutelings, Godfrey, additional, Hoffmann, Thomas, additional, Schwab, Wilfried, additional, El Jaziri, Mondher, additional, Behr, Marc, additional, and Baucher, Marie, additional

Published
2020
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10. NF-κB and Its Role in Checkpoint Control

Author

Betzler, Annika C., primary, Theodoraki, Marie-Nicole, additional, Schuler, Patrick J., additional, Döscher, Johannes, additional, Laban, Simon, additional, Hoffmann, Thomas K., additional, and Brunner, Cornelia, additional

Published
2020
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12. Characterization and Differentiation of the Tumor Microenvironment (TME) of Orthotopic and Subcutaneously Grown Head and Neck Squamous Cell Carcinoma (HNSCC) in Immunocompetent Mice.

Author

Brand, Matthias, Laban, Simon, Theodoraki, Marie-Nicole, Doescher, Johannes, Hoffmann, Thomas K., Schuler, Patrick J., and Brunner, Cornelia

Subjects
SQUAMOUS cell carcinoma, TUMOR microenvironment, T cells, CELL populations, B cells
Abstract

For the development and evaluation of new head and neck squamous cell carcinoma (HNSCC) therapeutics, suitable, well-characterized animal models are needed. Thus, by analyzing orthotopic versus subcutaneous models of HNSCC in immunocompetent mice, we evaluated the existence of adenosine-related immunosuppressive B- and T lymphocyte populations within the tumor microenvironment (TME). Applying the SCC VII model for the induction of HNSCC in immunocompetent C3H/HeN mice, the cellular TME was characterized after tumor initiation over time by flow cytometry. The TME in orthotopic grown tumors revealed a larger population of tumor-infiltrating lymphocytes (TIL) with more B cells and CD4+ T cells than the subcutaneously grown tumors. Immune cell populations in the blood and bone marrow showed a rather distinct reaction toward tumor induction and tumor location compared to the spleen, lymph nodes, or thymus. In addition, large numbers of immunosuppressive B- and T cells were identified within the TME but also in secondary lymphoid organs, independently of the tumor initiation site. The altered immunogenic TME may influence the response to any treatment attempt. Moreover, when analyzing the TME and other lymphoid organs of tumor-bearing mice, we observed conditions reflecting largely those of patients suffering from HNSCC suggesting the C3H/HeN mouse model as a suitable tool for studies aiming to target immunosuppression to improve anti-cancer therapies. [ABSTRACT FROM AUTHOR]

Published
2021
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