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Your search keyword '"Mao, Xiao"' showing total 8 results
Start Over Author "Mao, Xiao" Journal international journal of molecular sciences
8 results on '"Mao, Xiao"'

2. Proteomic Analysis of Mouse Brain Subjected to Spaceflight

Author

Mao, Xiao, primary, Sandberg, Lawrence, additional, Gridley, Daila, additional, Herrmann, E., additional, Zhang, Guangyu, additional, Raghavan, Ravi, additional, Zubarev, Roman, additional, Zhang, Bo, additional, Stodieck, Louis, additional, Ferguson, Virginia, additional, Bateman, Ted, additional, and Pecaut, Michael, additional

Published
2018
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5. PRRT2 Mutations Are Related to Febrile Seizures in Epileptic Patients

Author

He, Zheng-Wen, primary, Qu, Jian, additional, Zhang, Ying, additional, Mao, Chen-Xue, additional, Wang, Zhi-Bin, additional, Mao, Xiao-Yuan, additional, Deng, Zhi-Yong, additional, Zhou, Bo-Ting, additional, Yin, Ji-Ye, additional, Long, Hong-Yu, additional, Xiao, Bo, additional, Zhang, Yu, additional, Zhou, Hong-Hao, additional, and Liu, Zhao-Qian, additional

Published
2014
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8. Proteomic Analysis of Mouse Brain Subjected to Spaceflight.

Author

Mao, Xiao Wen, Sandberg, Lawrence B., Gridley, Daila S., Herrmann, E. Clifford, Zhang, Guangyu, Raghavan, Ravi, Zubarev, Roman A., Zhang, Bo, Stodieck, Louis S., Ferguson, Virginia L., Bateman, Ted A., and Pecaut, Michael J.

Subjects
*CENTRAL nervous system diseases, *PROTEIN expression, *PROTEOMICS
Abstract

There is evidence that spaceflight poses acute and late risks to the central nervous system. To explore possible mechanisms, the proteomic changes following spaceflight in mouse brain were characterized. Space Shuttle Atlantis (STS-135) was launched from the Kennedy Space Center (KSC) on a 13-day mission. Within 3–5 h after landing, brain tissue was collected to evaluate protein expression profiles using quantitative proteomic analysis. Our results showed that there were 26 proteins that were significantly altered after spaceflight in the gray and/or white matter. While there was no overlap between the white and gray matter in terms of individual proteins, there was overlap in terms of function, synaptic plasticity, vesical activity, protein/organelle transport, and metabolism. Our data demonstrate that exposure to the spaceflight environment induces significant changes in protein expression related to neuronal structure and metabolic function. This might lead to a significant impact on brain structural and functional integrity that could affect the outcome of space missions. [ABSTRACT FROM AUTHOR]

Published
2019
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