1. An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs.
- Author
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Koslowski S, Latapy C, Auvray P, Blondel M, and Meijer L
- Subjects
- Animals, Cysts complications, Disease Models, Animal, Disease Progression, Kidney pathology, Kidney Failure, Chronic complications, Models, Biological, Polycystic Kidney Diseases etiology, Polycystic Kidney Diseases metabolism, Swine, Swine, Miniature, Polycystic Kidney, Autosomal Dominant etiology, Polycystic Kidney, Autosomal Dominant genetics, Polycystic Kidney, Autosomal Dominant metabolism
- Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inheritable cause of end stage renal disease and, as of today, only a single moderately effective treatment is available for patients. Even though ADPKD research has made huge progress over the last decades, the precise disease mechanisms remain elusive. However, a wide variety of cellular and animal models have been developed to decipher the pathophysiological mechanisms and related pathways underlying the disease. As none of these models perfectly recapitulates the complexity of the human disease, the aim of this review is to give an overview of the main tools currently available to ADPKD researchers, as well as their main advantages and limitations.
- Published
- 2020
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