Search

Your search keyword '"STACHURA, ALBERT"' showing total 7 results
Start Over Author "STACHURA, ALBERT" Journal international journal of molecular sciences
7 results on '"STACHURA, ALBERT"'

1. Pre-Incisional and Multiple Intradermal Injection of N-Acetylcysteine Slightly Improves Incisional Wound Healing in an Animal Model

Author

Pascal, Wiktor, primary, Smoliński, Antoni, additional, Gotowiec, Mateusz, additional, Wojtkiewicz, Marta, additional, Stachura, Albert, additional, Pełka, Kacper, additional, Kopka, Michał, additional, Quinn, Kyle P., additional, Woessner, Alan E., additional, Grzelecki, Dariusz, additional, and Włodarski, Paweł, additional

Published
2024
Full Text
View/download PDF

2. The Influence of N-Acetylcysteine-Enriched Hydrogels on Wound Healing in a Murine Model of Type II Diabetes Mellitus.

Author

Stachura, Albert, Sobczak, Marcin, Kędra, Karolina, Kopka, Michał, Kopka, Karolina, and Włodarski, Paweł K.

Abstract

Diabetes mellitus (DM) severely impairs skin wound healing capacity, yet few treatment options exist to enhance this process. N-acetylcysteine (NAC) is an antioxidant that improves cellular proliferation and enhances wound healing in healthy animals, yet its use in the context of type II DM has not been studied. The aim of our research was to investigate the effect of topically applied NAC-enriched hydrogels on wound healing in a leptin-deficient murine wound model. Four excisional wounds were created on the backs of 20 db/db mice and were subsequently treated with hydrogels containing NAC at concentrations of 5%, 10% and 20% or placebo (control). Healing was monitored for 28 days; photographs of the wounds were taken on every third day. Wound tissues were harvested on days 3, 7, 14 and 28 to undergo histological examinations. Wounds treated with 5% NAC showed improved wound closure speed accompanied by an increased dermal proliferation area on microscopic assessment compared with other groups. Higher concentrations of NAC failed to show a beneficial effect on wound healing. 5% NAC improved early stages of wound healing in a murine model of type II DM by increasing wound closure speed, likely mediated by improved dermal proliferation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1α, MAPK1, TGFβ1 and Growth Factors in Rat Wound Healing

Author

Paskal, Wiktor, primary, Kopka, Michał, additional, Stachura, Albert, additional, Paskal, Adriana M., additional, Pietruski, Piotr, additional, Pełka, Kacper, additional, Woessner, Alan E., additional, Quinn, Kyle P., additional, Galus, Ryszard, additional, Wejman, Jarosław, additional, and Włodarski, Paweł, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results