1. Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury
- Author
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Alessio Ardizzone, Marika Cordaro, Michela Campolo, Emanuela Esposito, Sarah Adriana Scuderi, Alfredo Conti, Rosalia Crupi, Rosalba Siracusa, Salvatore Massimo Cardali, Salvatore Cuzzocrea, Giovanna Casili, Campolo M., Crupi R., Cordaro M., Cardali S.M., Ardizzone A., Casili G., Scuderi S.A., Siracusa R., Esposito E., Conti A., and Cuzzocrea S.
- Subjects
Amide ,Male ,Palmitic Acid ,Administration, Oral ,Endogeny ,patients ,chemistry.chemical_compound ,Random Allocation ,Neurotrophic factors ,Morris Water Maze Test ,Brain Injuries, Traumatic ,Medicine ,Ethanolamine ,Biology (General) ,Spectroscopy ,Patient ,traumatic brain injury ,Neurogenesis ,General Medicine ,Middle Aged ,Computer Science Applications ,neurogenesis ,Chemistry ,Memory, Short-Term ,Treatment Outcome ,Ethanolamines ,Drug Therapy, Combination ,Female ,Human ,Adult ,mice ,Traumatic brain injury ,QH301-705.5 ,Spatial Learning ,Palmitic Acids ,Luteolin ,Mice ,Palmitoylethanolamide ,Patients ,Catalysis ,Article ,Inorganic Chemistry ,Downregulation and upregulation ,Animals ,Humans ,Physical and Theoretical Chemistry ,luteolin ,Molecular Biology ,palmitoylethanolamide ,QD1-999 ,Aged ,Animal ,business.industry ,Working memory ,Organic Chemistry ,medicine.disease ,Amides ,nervous system diseases ,Disease Models, Animal ,nervous system ,chemistry ,Neurogenesi ,business ,Neuroscience - Abstract
This study aimed to assess the neuro-regenerative properties of co-ultramicronized PEALut (Glialia®), composed of palmitoylethanolamide (PEA) and the flavonoid luteolin (Lut), in an in vivo model of traumatic brain injury (TBI) and patients affected by moderate TBI. An increase in neurogenesis was seen in the mice at 72 h and 7 d after TBI. The co-ultra PEALut treatment helped the neuronal reconstitution process to restore the basal level of both novel and mature neurons, moreover, it induced a significant upregulation of the neurotrophic factors, which ultimately led to progress in terms of memory recall during behavioral testing. Moreover, our preliminary findings in a clinical trial suggested that Glialia® treatment facilitated neural recovery on working memory. Thus, co-ultra PEALut (Glialia®) could represent a valuable therapeutic agent for intensifying the endogenous repair response in order to better treat TBI.
- Published
- 2021