1. The Role of the Thalamus in Post-Traumatic Stress Disorder
- Author
-
Takanobu Yoshii
- Subjects
Eye Movement Desensitization Reprocessing ,medicine.medical_treatment ,Psychological intervention ,Review ,Oxytocin ,Pulvinar ,EMDR ,Stress Disorders, Post-Traumatic ,lcsh:Chemistry ,0302 clinical medicine ,Conditioning, Psychological ,morphology ,Eye movement desensitization and reprocessing ,lcsh:QH301-705.5 ,Spectroscopy ,Hyperbaric Oxygenation ,fMRI ,Traumatic stress ,PTSD ,Fear ,General Medicine ,Amygdala ,Computer Science Applications ,Diffusion Tensor Imaging ,Treatment Outcome ,medicine.anatomical_structure ,Mental health care ,Clinical psychology ,Superior Colliculi ,Thalamus ,Lifetime prevalence ,Retina ,Catalysis ,Inorganic Chemistry ,03 medical and health sciences ,thalamus ,Connectome ,medicine ,Animals ,Humans ,Visual Pathways ,Physical and Theoretical Chemistry ,Molecular Biology ,Mechanism (biology) ,business.industry ,Organic Chemistry ,030227 psychiatry ,Disease Models, Animal ,lcsh:Biology (General) ,lcsh:QD1-999 ,nervous system ,business ,030217 neurology & neurosurgery - Abstract
Post-traumatic stress disorder (PTSD) has a high lifetime prevalence and is one of the more serious challenges in mental health care. Fear-conditioned learning involving the amygdala has been thought to be one of the main causative factors; however, recent studies have reported abnormalities in the thalamus of PTSD patients, which may explain the mechanism of interventions such as eye movement desensitization and reprocessing (EMDR). Therefore, I conducted a miniature literature review on the potential contribution of the thalamus to the pathogenesis of PTSD and the validation of therapeutic approaches. As a result, we noticed the importance of the retinotectal pathway (superior colliculus−pulvinar−amygdala connection) and discussed therapeutic indicators.
- Published
- 2021
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