1. Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces
- Author
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Kenji Mitsudo, Toshinori Iwai, Ryotaro Ozawa, Yasuharu Yajima, Takahiro Ogawa, Makoto Hirota, Hiroaki Kitajima, Mitomu Kioi, Yuichiro Hayashi, Masaki Iida, Kosuke Hamajima, and Toshiyuki Koizumi
- Subjects
0301 basic medicine ,medicine.medical_treatment ,Fibrinogen ,lcsh:Chemistry ,Contact angle ,Plasma ,0302 clinical medicine ,Blood plasma ,ultraviolet ,blood flow ,Dental implant ,lcsh:QH301-705.5 ,contact angle ,Spectroscopy ,dental implant surface ,Titanium ,Chemistry ,General Medicine ,Computer Science Applications ,Hydrophobic and Hydrophilic Interactions ,medicine.drug ,Surface Properties ,Ultraviolet Rays ,chemistry.chemical_element ,computational fluid dynamics ,Molecular Dynamics Simulation ,Models, Biological ,Catalysis ,Osseointegration ,Article ,Inorganic Chemistry ,03 medical and health sciences ,medicine ,Humans ,Physical and Theoretical Chemistry ,Molecular Biology ,Dental Implants ,Wound Healing ,Organic Chemistry ,030206 dentistry ,Blood flow ,030104 developmental biology ,lcsh:Biology (General) ,lcsh:QD1-999 ,Implant ,hydrophilicity ,Biomedical engineering - Abstract
Ultraviolet treatment of titanium implants makes their surfaces hydrophilic and enhances osseointegration. However, the mechanism is not fully understood. This study hypothesizes that the recruitment of fibrinogen, a critical molecule for blood clot formation and wound healing, is influenced by the degrees of hydrophilicity/hydrophobicity of the implant surfaces. Computational fluid dynamics (CFD) implant models were created for fluid flow simulation. The hydrophilicity level was expressed by the contact angle between the implant surface and blood plasma, ranging from 5°, (superhydrophilic), 30°, (hydrophilic) to 50°, and 70°, (hydrophobic), and 100°, (hydrorepellent). The mass of fibrinogen flowing into the implant interfacial zone (fibrinogen infiltration) increased in a time dependent manner, with a steeper slope for surfaces with greater hydrophilicity. The mass of blood plasma absorbed into the interfacial zone (blood plasma infiltration) was also promoted by the hydrophilic surfaces but it was rapid and non-time-dependent. There was no linear correlation between the fibrinogen infiltration rate and the blood plasma infiltration rate. These results suggest that hydrophilic implant surfaces promote both fibrinogen and blood plasma infiltration to their interface. However, the infiltration of the two components were not proportional, implying a selectively enhanced recruitment of fibrinogen by hydrophilic implant surfaces.
- Published
- 2019