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Start Over Author "Wencai Zhang" Journal international journal of molecular sciences
2 results on '"Wencai Zhang"'

1. Associations between Variants in IL-33/ST2 Signaling Pathway Genes and Coronary Heart Disease Risk

Author

Fangqin Wu, Mei'an He, Qiang Wen, Wencai Zhang, Jinhua Yang, Xiaomin Zhang, Tangchun Wu, and Longxian Cheng

Subjects
coronary artery disease, ST2, IL-33, IL-1RAcP, signaling pathway, gene, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The IL-33/ST2 signaling pathway plays an important role in coronary artery disease (CHD); however, few studies have explored how variants in IL-33/ST2 genes influence CHD risk. Here, we examined the association between genetic variants in IL-33, ST2, and IL-1RAcP of the IL-33/ST2 axis and the risk of CHD. We conducted a case-controlled study with 1146 CHD cases and 1146 age- and sex-frequency-matched controls. Twenty-eight single nucleotide polymorphisms (SNPs) in IL-33, ST2, and IL-1RAcP were genotyped by Sequenom MassArray and TaqMan assay. Logistic regression was used to analyze these associations. The SNP rs4624606 in IL-1RAcP was nominally associated with CHD risk. The AA genotype was associated with a 1.85-fold increased risk of CHD (95% confidence interval (CI) = 1.01–3.36; p = 0.045) compared to the TT genotype. Further analysis showed that AA carriers also had a higher risk of CHD than TT + TA carriers (odds ratio (OR) = 1.85; 95% CI = 1.85–3.35; p = 0.043). However, no significant association was observed between variants in IL-33/ST2 genes and CHD risk. Further studies are needed to replicate our results in other ethnic groups with larger sample size.

Published
2014
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2. Associations between Variants in IL-33/ST2 Signaling Pathway Genes and Coronary Heart Disease Risk

Author

Meian He, Tangchun Wu, Qiang Wen, Jinhua Yang, Xiaomin Zhang, Fangqin Wu, Wencai Zhang, and Longxian Cheng

Subjects
Male, Oncology, signaling pathway, medicine.medical_specialty, Receptors, Cell Surface, Single-nucleotide polymorphism, Biology, Logistic regression, Bioinformatics, Polymorphism, Single Nucleotide, Article, Catalysis, Inorganic Chemistry, Coronary artery disease, lcsh:Chemistry, Internal medicine, Genotype, medicine, Humans, SNP, cardiovascular diseases, Physical and Theoretical Chemistry, gene, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, Aged, Interleukins, Organic Chemistry, Case-control study, General Medicine, Odds ratio, Middle Aged, Interleukin-33, medicine.disease, ST2, Interleukin-1 Receptor-Like 1 Protein, Confidence interval, Computer Science Applications, IL-1RAcP, lcsh:Biology (General), lcsh:QD1-999, Case-Control Studies, IL-33, Female, Interleukin-1 Receptor Accessory Protein, coronary artery disease
Abstract

The IL-33/ST2 signaling pathway plays an important role in coronary artery disease (CHD), however, few studies have explored how variants in IL-33/ST2 genes influence CHD risk. Here, we examined the association between genetic variants in IL-33, ST2, and IL-1RAcP of the IL-33/ST2 axis and the risk of CHD. We conducted a case-controlled study with 1146 CHD cases and 1146 age- and sex-frequency-matched controls. Twenty-eight single nucleotide polymorphisms (SNPs) in IL-33, ST2, and IL-1RAcP were genotyped by Sequenom MassArray and TaqMan assay. Logistic regression was used to analyze these associations. The SNP rs4624606 in IL-1RAcP was nominally associated with CHD risk. The AA genotype was associated with a 1.85-fold increased risk of CHD (95% confidence interval (CI) = 1.01–3.36, p = 0.045) compared to the TT genotype. Further analysis showed that AA carriers also had a higher risk of CHD than TT + TA carriers (odds ratio (OR) = 1.85, 95% CI = 1.85–3.35, p = 0.043). However, no significant association was observed between variants in IL-33/ST2 genes and CHD risk. Further studies are needed to replicate our results in other ethnic groups with larger sample size.

Published
2014

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