1. The Effect of Toll-Like Receptor 4 in the Aqueous Humor of Endotoxin-Induced Uveitis
- Author
-
Shang Li, Jing Wang, Xiaofeng Hu, Hong Lu, Wei Chen, and Yingzhi Xu
- Subjects
Lipopolysaccharides ,Male ,Lipopolysaccharide ,medicine.medical_treatment ,Biology ,Catalysis ,Article ,lcsh:Chemistry ,Inorganic Chemistry ,Aqueous Humor ,Uveitis ,chemistry.chemical_compound ,Interferon-gamma ,Mice ,medicine ,Animals ,Physical and Theoretical Chemistry ,Anterior Uveitis ,lcsh:QH301-705.5 ,Molecular Biology ,Cytokine ,Spectroscopy ,Toll-like receptor ,Mice, Inbred C3H ,cytometric bead array technology ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,Organic Chemistry ,Interleukin ,General Medicine ,medicine.disease ,Toll-like receptor 4 ,Computer Science Applications ,Interleukin-10 ,Endotoxins ,Interleukin 10 ,lcsh:Biology (General) ,lcsh:QD1-999 ,chemistry ,Immunology ,TLR4 ,Tumor necrosis factor alpha ,lipids (amino acids, peptides, and proteins) ,Interleukin-1 ,Signal Transduction - Abstract
In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.
- Published
- 2012